PURPOSE: To purify and obtain industrially and advantageously the titled compound useful as medicines in high purity, by treating a solution containing a specific aminosulfonic acid compound with both ion exchangers having respectively sulfonic acid groups and quaternary ammonium groups.
CONSTITUTION: A solution containing an aminosulfonic acid of the formula (R1 and R2 are H or methyl; X is O or S or C-S bond through no X; n is an integer 1W3) is treated with both of (A) an ion exchanger having sulfonic acid groups and (B) an ion exchanger having quaternary ammonium groups to purify the aminosulfonic acid compound. "Diaion SK" series (tradename; manufactured by Mitsubishi Chemical Industries Ltd.), etc. is preferred for the ion exchanger (A), and "Diaion SA" series (manufactured by the same company) is preferred for the ion exchanger (B). The use of the above-mentioned method in the final step of the purification process at the removal of impurities to some extent permits the treatment of the compound of the formula in large quantities by using a small amount of the resin.
OOSAWA YASUKO
UCHIKUGA SABUROU
| JPS5770858A | 1982-05-01 |