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Title:
METHOD FOR PURIFYING DIDEOXYINOSINE
Document Type and Number:
Japanese Patent JPH01165390
Kind Code:
A
Abstract:
PURPOSE:To simply and efficiently separate and purify dideoxyinosine at a low cost, by treating 2',3'-dideoxyinosine produced by action of a microorganism or enzyme with a nonpolar porous resin. CONSTITUTION:A solution containing unpurified 2',3'-dideoxyinosine produced by action of a microorganism or enzyme is subjected to, e.g., sterilization, deproteinization and decoloring treatment, and then brought into contact with a nonpolar porous resin, e.g., styrene-divinylbenzene based copolymer or a derivative thereof, to adsorb the 2',3'-dideoxyinosine on the above-mentioned resin. An aqueous solution of a lower aliphatic alcohol is subsequently used as an eluent to elute the 2',3'-dideoxyinosine from the afore-mentioned resin and the eluate is preferably concentrated to crystallize the aimed 2',3'-dideoxyinosine.

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Inventors:
TANABE TOSHIYA
OTANI MASARU
YUGAWA TOSHIHIDE
Application Number:
JP32453187A
Publication Date:
June 29, 1989
Filing Date:
December 22, 1987
Export Citation:
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Assignee:
AJINOMOTO KK
International Classes:
C12P17/18; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7076; A61K31/708; A61P31/12; C07D473/28; C07H19/16; (IPC1-7): A61K31/71; C07H19/16; C12P17/18



 
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