Title:
METHOD FOR QUANTITATIVELY DETERMINING NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS
Document Type and Number:
Japanese Patent JP2012053025
Kind Code:
A
Abstract:
To provide a method for quantitatively determining nitrogen-containing heterocyclic compounds or salts thereof which allows a user to pretreat specimens simply and allows a user to pretreat many specimens in a short time.
A determination method includes the steps of: subjecting specimens containing a nitrogen-containing heterocyclic compound represented by general formula (I) (in the formula, R represents a linear or a branched alkyl group having 1 to 4 carbon atoms) or a pharmaceutical acceptable salt thereof to deproteinization-treatment; and quantitatively determining the resulting specimens treated by the deproteinization-treatment by a liquid chromatography or a tandem mass spectrometry.
Inventors:
MORI TERUYO
YOKOHATA KAZUYO
WATANABE YUKIHIKO
YOKOHATA KAZUYO
WATANABE YUKIHIKO
Application Number:
JP2010231754A
Publication Date:
March 15, 2012
Filing Date:
October 14, 2010
Export Citation:
Assignee:
MARUISHI PHARMA
International Classes:
G01N27/62; G01N30/26; G01N30/72; G01N33/50
Domestic Patent References:
| JP2009139177A | 2009-06-25 | |||
| JP2006112835A | 2006-04-27 | |||
| JP2004526804A | 2004-09-02 | |||
| JP2009139177A | 2009-06-25 |
Foreign References:
| US20050043288A1 | 2005-02-24 | |||
| US20050043288A1 | 2005-02-24 |
Other References:
JPN6014032016; Ａ． Ｋｏｅｈｌｅｒ ｅｔ ａｌ．: '"Ｓｉｍｕｌｔａｎｅｏｕｓ ｄｅｔｅｒｍｉｎａｔｉｏｎ ｏｆ ｂｕｐｉｖａｃａｉｎｅ， ｍｅｐｉｖａｃａｉｎ， ｐｒｉｌｏｃａｉｎｅ ａｎｄ ｒｏｐｉｖａｃａｉｎ ｉｎ ｈｕｍａｎ ｓｅｒｕｍ ｂｙ' Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ Ｖｏｌ． １０８８， Ｎｏ． １-２, 20050923, ｐ． １２６-１３０, Ｅｌｓｅｖｉｅｒ Ｂ．Ｖ．
JPN6014032017; Ｌｅｏｎａｒｄｏ Ｓ． Ｓａｎｔｏｓ ｅｔ ａｌ．: '"Ｆａｓｔ Ｓｃｒｅｅｎｉｎｇ ｏｆ Ｌｏｗ Ｍｏｌｅｃｕｌａｒ Ｗｅｉｇｈｔ Ｃｏｍｐｏｕｎｄｓ ｂｙ Ｔｈｉｎ-Ｌａｙｅｒ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ ａｎｄ ''Ｏｎ-Ｓｐｏｔ'' ＭＡＬＤＩ' Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ． ７６， Ｎｏ． ７, 20040401, ｐ． ２１４４-２１４７, Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ
JPN6014032017; Ｌｅｏｎａｒｄｏ Ｓ． Ｓａｎｔｏｓ ｅｔ ａｌ．: '"Ｆａｓｔ Ｓｃｒｅｅｎｉｎｇ ｏｆ Ｌｏｗ Ｍｏｌｅｃｕｌａｒ Ｗｅｉｇｈｔ Ｃｏｍｐｏｕｎｄｓ ｂｙ Ｔｈｉｎ-Ｌａｙｅｒ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ ａｎｄ ''Ｏｎ-Ｓｐｏｔ'' ＭＡＬＤＩ' Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ． ７６， Ｎｏ． ７, 20040401, ｐ． ２１４４-２１４７, Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ
Attorney, Agent or Firm:
Ryu Iwatani