PURPOSE: To obtain a ring closure compound useful as a synthetic intermediate for a lactam-based compound useful as antimicrobial agent, analgesic, hypnotic, etc., by radically reacting a dienylamide with a disulfide.
CONSTITUTION: A dienylamide compound shown by formula I (R1 is aryl, aralkyl or aliphatic hydrocarbon residue; R2 to R4 are H or lower alkyl; R5 and R6 are H or mutually bond to form trimethylene; (n) is 0 or 1) is reacted with a disulfide compound shown by the formula (RS)2 (R is aryl or alkyl in the presence or absence of a thiol compound shown by the formula RSH in an inert solvent (e.g. benzene) at room temperature to 100°C for 1-24 hours to give the objective compound shown by formula II (R7 and R8 are H or group RS). The amount of the disulfide used is 0.5-1mol based on 1mol of the compound shown by formula I and that of the thiol compound is 0.5-1mol.
NINOMIYA KAZUYA
MIYATA KYOKO
