Title:
カルボマー中の残留有機溶媒の低減方法
Document Type and Number:
Japanese Patent JP2005523951
Kind Code:
A
Abstract:
Method for reducing the level of residual organic solvent in a carbomer comprising exposing a carbomer containing residual organic solvent to a gaseous fluid in which said residual organic solvent is substantially soluble and under conditions sufficient to extract at least some of the residual organic solvent from the carbomer; carbomers treated by this method and pharmaceutical suspensions containing the treated carbomer and a therapeutically active agent. This method is effective for the reduction of residual organic solvent in carbomer down to the ppm level, e.g., less than 30 ppm, preferably less than 10 ppm, more preferably less than 2 ppm of residual organic solvent.
Inventors:
Fornes Cecil
Horhotah steven tea
Same Sed
Bokuniak david
Horhotah steven tea
Same Sed
Bokuniak david
Application Number:
JP2003587847A
Publication Date:
August 11, 2005
Filing Date:
April 21, 2003
Export Citation:
Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
International Classes:
C07D471/14; A61K9/10; A61K31/551; A61K47/32; A61P31/12; B01D11/00; B01D11/02; C08F6/00; C08F6/10; C08F6/28; C08F20/00; A61K47/10; (IPC1-7): C08F6/10; A61K9/10; A61K31/551; A61K47/32; A61P31/12; B01D11/00; C08F20/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama