Title:
METHOD FOR REMOVING PROTECTING GROUP
Document Type and Number:
Japanese Patent JP2689412
Kind Code:
B2
Abstract:
PURPOSE: To provide a method for removing a protecting group in which a tri-substituted silyl group can efficiently be removed under mild conditions and the objective compound can be obtained in high yield at a low cost.
CONSTITUTION: This method for removing a tri-substituted silyl group is to treat a β-lactam compound having hydroxyl group protected with the tri- substituted silyl group with a fluoride selected from (a) an alkali metallic fluoride, (b) an alkaline earth metallic fluoride and (c) hydrofluoride of an inorganic or an organic amine and an acid.
Inventors:
Kazuhiko Kondo
Horikawa Satoshi
Iwa Saki Tameo
Horikawa Satoshi
Iwa Saki Tameo
Application Number:
JP9581893A
Publication Date:
December 10, 1997
Filing Date:
April 22, 1993
Export Citation:
Assignee:
Tanabe Pharmaceutical Co., Ltd.
International Classes:
A61K31/545; A61K31/397; A61K31/546; A61P31/04; C07B41/02; C07B51/00; C07D463/00; C07D477/00; C07D499/04; C07D499/06; C07D499/88; C07D499/893; C07D499/897; C07D501/04; C07F7/08; (IPC1-7): C07B51/00; C07B41/02; C07D499/04; C07D501/04
Other References:
JOURNAL OF ORGANIC CHEMISTRY,=1990
TETRAHEDRON LETTERS,=1980
TETRAHEDRON LETTERS,=1980
Attorney, Agent or Firm:
Shigeo Minoura
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