METHOD FOR RESOLUTION OF ALPHA AMINONITRILE OF RACEMIC BODY

Title:

METHOD FOR RESOLUTION OF ALPHA AMINONITRILE OF RACEMIC BODY

Document Type and Number:

Japanese Patent JPS53127434

Kind Code:

A

Abstract:

Process for the resolution of certain racemic alpha -aminonitriles into optically active enantiomers which includes treating the racemic alpha -aminonitriles with (-)-mandelic acid in an alkanol/C5-8 hydrocarbon mixture to obtain a racemic mixture of diastereoisomeric D and L salts of (-)-mandelic acid, macerating the salts with an alkanol/C5-8 hydrocarbon mixture; neutralizing the L-form; extracting the neutralized product; and converting it into a stable form.

More Like This:

JPS52139041	CYANOMETHYL PHENETHANOL AMINES
JP4091837	A method for producing an asymmetric aminonitrile derivative using a solid-phase-supported optically active binaphthyl and a solid-phase-supported optically active binaphthyl.
JP2017503769	Selective MAO-B inhibitor compound, its pharmaceutical composition and its use

Inventors:

MARIYAN HONJIETSUKU
MIHA YABERI

Application Number:

JP4043478A

Publication Date:

November 07, 1978

Filing Date:

April 07, 1978

Export Citation:

Click for automatic bibliography generation Help

Assignee:

KRKA FARMA

International Classes:

C07C255/43; A61H23/00; A61K31/275; C07B57/00; C07C67/00; C07C253/00; C07C255/53; C07C255/58; C07C255/59; C07C; (IPC1-7): C07C121/78

Domestic Patent References:

JPS4920306A

1974-02-22

Previous Patent: JPS53127433

Next Patent: 44ALKYLTHIOO22TRIFLORMETHYLALKAN SULFONANILID AND THOSE DERIVATIVE