To search a compound capable of inhibiting tumor growth by contacting a test sample with an expression cell for RecQ DNA helixase family gene to measure the expression level of the gene and by selecting a compound for lowering the expression level.
This method for screening a compound capable of inhibiting tumor growth is to contact (and/or to transform) a test sample with (and/or into) a cell comprising an expression cell strain for RecQ DNA helixase family gene or the like to measure the expression level of the RecQ DNA helixase family gene and to select a compound for lowering the expression level of the RecQ DNA helixase family gene. The measurement of the gene expression level is carried out by measuring the helixase expression level in a human tumor cell system by the western blotting method using a monoclonal antibody capable of recognizing an C-terminal epitope.
SUGIMOTO MASANOBU
MATSUMOTO TAKEHISA
SHIRATORI YOSHIKAZU
GOTO MAKOTO
