To provide respective methods of high generality for producing an anomer-selective 1-phosphorylated saccharide derivative and a nucleoside, each independent of the difference in saccharide skeleton such as furanose or pyranose, the presence/absence of substituent such as deoxysaccharides, and the kind of saccharide such as natural type or non-natural type.
The method for producing the anomer-selective 1-phosphorylated saccharide derivative comprises the following process: an anomer mixture of 1-phosphorylated saccharide derivatives is put to phosphorolysis and isomerization reaction, and either one of the products is crystallized to break the equilibrium to selectively obtain the aimed isomer alone. The method for producing the nucleoside comprises making a nucleoside phosphorylase act on the thus obtained 1-phosphorylated saccharide derivative in the presence of a base to obtain the aimed nucleoside in high stereoselectivity and yield.
AWANO HIROICHI
FUKAZAWA NOBUYUKI
ITO KIYOSHI
IKEDA ICHIRO
ARAKI TADASHI
NAKAMURA TAKESHI
ASANO TAMOTSU
FUJIWARA JUNYA
ANDO TOMOYUKI
TSUCHIYA KATSUTOSHI
MARUYAMA KYOKO
UMETANI HIDETAKE
YAMAUCHI TAKAHIRO
MIYAKE JINKI
| JPH05247078A | 1993-09-24 | |||
| JPH02256697A | 1990-10-17 | |||
| JPS61501919A | 1986-09-04 | |||
| JPH01137290A | 1989-05-30 |
| DE3834877A1 | 1990-05-03 | |||
| US5770407A | 1998-06-23 |