Title:
METHOD FOR SELECTIVELY PRODUCING (+)-CIS-SERTRALINE
Document Type and Number:
Japanese Patent JP2013103935
Kind Code:
A
Abstract:
To provide a method for selectively producing (+)-cis-sertraline represented by formula 1 and usable as an intermediate in the production of sertraline hydrochloride.
The method for producing the (+)-cis-sertraline represented by formula 1 includes a step for producing (+)-cis-sertraline (S)-(-)-2-pyrrolidone-5-carboxylate by reacting (±)-cis/trans-sertraline or (±)-cis-sertraline with (S)-(-)-2-pyrrolidone-5-carboxylic acid, and carrying out optical resolution thereof.
Inventors:
KIM JE HAK
LEE JOON KWANG
SUN YONGHO
LEE SEONGGUK
NAM EUNHYE
LEE JOON KWANG
SUN YONGHO
LEE SEONGGUK
NAM EUNHYE
Application Number:
JP2012245642A
Publication Date:
May 30, 2013
Filing Date:
November 07, 2012
Export Citation:
Assignee:
BORYUNG PHARM
International Classes:
C07C209/88; C07C211/42; C07B57/00
Domestic Patent References:
| JPS5686137A | 1981-07-13 | |||
| JP2009500425A | 2009-01-08 |
Attorney, Agent or Firm:
Takashima Ichi