Title:
METHOD FOR SEPARATING ENANTIOMER OF 3,6-DIHYDRO-1,3,5-TRIAZINE AMINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2015129121
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for obtaining a dihydro-1,3,5-triazine amine derivative useful as a pharmaceutical composition in a high yield and high excess enantiomorph ratio.SOLUTION: There is provided a method for separating an enantiomer of a dihydro-1,3,5-triazine amine derivative represented by the formula (1) by chromatography having a specified chiral ion exchanger. [Rand Rare A; Rand Rare H; Ris H; Ris A; A is an unbranched/branched alkyl group having 1 to 10 carbon atoms; 1 to 7 H atoms of the alkyl group are substituted/unsubstituted with F or a cyclic alkyl having 3 to 7 carbon atoms.]
Inventors:
MATTHIAS HELMREICH
CLAUS-PETER NIESERT
MICHAEL SCHULTE
WOLFGANG LINDNER
MICHAEL LAEMMERHOFER
CHRISTIAN HOFFMANN
CLAUS-PETER NIESERT
MICHAEL SCHULTE
WOLFGANG LINDNER
MICHAEL LAEMMERHOFER
CHRISTIAN HOFFMANN
Application Number:
JP2014258677A
Publication Date:
July 16, 2015
Filing Date:
December 22, 2014
Export Citation:
Assignee:
MERCK PATENT GMBH
International Classes:
C07B57/00; C07D251/10; G01N30/26; G01N30/88
Domestic Patent References:
| JP2011522684A | 2011-08-04 | |||
| JP2005517196A | 2005-06-09 | |||
| JP2008521600A | 2008-06-26 | |||
| JP2006522753A | 2006-10-05 | |||
| JP2005010112A | 2005-01-13 |
Foreign References:
| WO1997046557A1 | 1997-12-11 |
Other References:
JPN6015052783; Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ ８０（２２）, 2008, ８７８０-８７８９
JPN6015052786; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１６１, 2007, ２４２-２５１
JPN6015052786; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ａ １１６１, 2007, ２４２-２５１
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata