Title:
METHOD FOR SEPARATION OF INTERMEDIATE WHICH MAY BE USED FOR PREPARATION OF ESCITALOPRAM
Document Type and Number:
Japanese Patent JP2011055842
Kind Code:
A
Abstract:
To provide a new method for preparation of optically active intermediates which may be used for the preparation of escitalopram.
There is provided a method for isolation and purification of S-enantiomer of the diol represented by formula (II), and its acylated derivative. The method includes treating the mixture of the S-enantiomer of the diol and its acylated derivative in the mixture of an organic solvent and water in the presence of an acid, and then performing liquid-liquid separation. In the formula, R is cyano group or the like; the dotted line represents a double or single bond; Hal is halogen; and Z is dimethylamino or the like.
Inventors:
TAOKA NAOAKI
KATO TAKAHISA
YAMAMOTO SHOGO
YOSHIDA TAKASHI
TAKEDA TOSHIHIRO
UEDA YASUYOSHI
PETERSEN HANS
DANCER ROBERT
AHMADIAN HALEH
LYNGSO LARS OLE
KATO TAKAHISA
YAMAMOTO SHOGO
YOSHIDA TAKASHI
TAKEDA TOSHIHIRO
UEDA YASUYOSHI
PETERSEN HANS
DANCER ROBERT
AHMADIAN HALEH
LYNGSO LARS OLE
Application Number:
JP2010262040A
Publication Date:
March 24, 2011
Filing Date:
November 25, 2010
Export Citation:
Assignee:
LUNDBECK & CO AS H
International Classes:
C12P13/00; C07B57/00; C12P41/00; C07C253/30; C07C253/34; C07C255/34; C07C255/53; C07C255/59; C07D307/87
Domestic Patent References:
| JPH11292867A | 1999-10-26 | |||
| JPH0236177A | 1990-02-06 | |||
| JPS52105162A | 1977-09-03 | |||
| JPS6187654A | 1986-05-06 | |||
| JP2002509864A | 2002-04-02 |
Foreign References:
| WO2000012044A2 | 2000-03-09 | |||
| WO1998019511A2 | 1998-05-14 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki