METHOD FOR SILK FIBROIN GELATION USING SONICATION

Japanese Patent JP2015145500

A

PROBLEM TO BE SOLVED: To provide a method of rapidly forming silk fibroin gelation and a method of encapsulating materials in silk fibroin.SOLUTION: A ultrasonication method for silk fibrin comprises: exposing silk fibroin, under the appropriate conditions concerning the silk fibrin concentration, added salts and the pH, to a treatment comprising ultrasonication for a sufficient period of time to initiate gelation in which the gelation forms substantially within 24 hours after the ultrasonication treatment; controlling the gelation to occur within two hours after the ultrasonication treatment; encapsulating biological materials, including viable cells, or therapeutic agents in hydrogels formed by the method; and allowing them to be used as delivery vehicles.

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WANG XIAOQIN
JON KLUGE
GARY G LEISK
DAVID L KAPLAN

JP2015053556A

August 13, 2015

March 17, 2015

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TUFTS COLLEGE

C08J3/075; A61K9/06; A61K31/7088; A61K35/12; A61K38/00; A61K38/22; A61K38/27; A61K38/43; A61K39/395; A61K47/42; C08J3/21; C08L89/00

JPH0284503A	1990-03-26
JPS56163658A	1981-12-16
JPH0488027A	1992-03-19

WO2005123114A2	2005-12-29
WO2005123114A2	2005-12-29

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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