Title:
METHOD FOR SUPPRESSING LOSS OF BONE AND DEGENERATION OF CARTILAGE BY USING WORT- MANNIN AND ITS ANALOG
Document Type and Number:
Japanese Patent JPH07149651
Kind Code:
A
Abstract:
PURPOSE: To obtain an inexpensive inhibitor of bone resorption or cartilage degradation containing wortmannin and its analog as active ingredients and free from adverse effects. CONSTITUTION: This inhibitor contains a compound selected from a group comprising compounds of formula I (R is H or acetoxy; R' is a 1-6C alkyl), formula II, formula III (R" is H, a 1-6C alkyl or C(O)OR"'; R"' is H or a 1-6C alkyl), formula IV (R<1> is H, methyl or ethyl; R<2> is H or methyl) or its salt as an active ingredient. The compound is obtained by culturing A 24603.1 strain and isolating and purifying the cultured product. Bone resorption proceeds by operation of osteoclast (same as chondroclast) and osteoclast has abilities to resorb both of hydroxyapatite inorganic material and organic matrix of bone. The inhibitor is useful for bone loss-related diseases such as osteoporosis after menopause and daily dose of the inhibitor is 0.001-10 mg/kg.
Inventors:
JIEFURII ARAN DOTSUJI
MASAHIKO SATOO
MASAHIKO SATOO
Application Number:
JP19946794A
Publication Date:
June 13, 1995
Filing Date:
August 24, 1994
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
C12P33/00; A61K31/365; A61K31/58; A61P1/00; A61P3/00; A61P19/10; C07J73/00; C12R1/80; (IPC1-7): A61K31/58; A61K31/58; C07J73/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
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