Title:
１９−ノルプレグナ−４−エン−３，２０−ジオン−１７．α．−オール（ゲストノロン）の合成方法及びその中間体
Document Type and Number:
Japanese Patent JP6453337
Kind Code:
B2
Abstract:
The present invention relates to a new stereoselective process for the synthesis of 17(α)-17-acetyl-17-hydroxy-estr-4-en-3-one of formula (I), as well as to the new intermediates of the process. The 17(α)-17-acetyl-17-hy droxy-estr-4-en-3 -one (gestonorone) is an important intermediate in the synthesis of the active ingredients having progestogen activity - such as gestonorone capronate and nomegestroi acetate. Formulas (I), (II) and (III).
Inventors:
Cergay, Janos
Holverse, Anita
Shanta, Chaba
Maho, shandol
Beni, Zoltan
Holverse, Janos
Holverse, Anita
Shanta, Chaba
Maho, shandol
Beni, Zoltan
Holverse, Janos
Application Number:
JP2016539916A
Publication Date:
January 16, 2019
Filing Date:
December 15, 2014
Export Citation:
Assignee:
Richter Gedeon NRW.
International Classes:
C07J7/00; C07C401/00; C07F7/18; C07J3/00
Domestic Patent References:
| JP48026751A |
Foreign References:
| US3423435 | ||||
| DD289540A1 | ||||
| US3381003 | ||||
| US2781365 |
Other References:
ARBEZ-GINDRE,C. et al.,Methyl exchange on silicon during the addition of methylmagnesium iodide to a cyanohydrin O-silyl ether,Chemical Communications(Cambridge),1999年,No.5,p.431-432
CROCQ,V. et al.,Synthesis of trimegestone: the first industrial application of bakers' yeast mediated reduction of a ketone,Organic Process Research & Development,1997年,Vol.1, No.1,p.2-13
GASC,J.C. et al.,New approach to corticoid total synthesis,Tetrahedron Letters,1971年,No.22,p.2005-2008
CROCQ,V. et al.,Synthesis of trimegestone: the first industrial application of bakers' yeast mediated reduction of a ketone,Organic Process Research & Development,1997年,Vol.1, No.1,p.2-13
GASC,J.C. et al.,New approach to corticoid total synthesis,Tetrahedron Letters,1971年,No.22,p.2005-2008
Attorney, Agent or Firm:
Konno Akio
Minoru Inami
Takeyasu Ito
Keisei Tamura
Minoru Inami
Takeyasu Ito
Keisei Tamura