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Title:
METHOD FOR SYNTHESIZING 2,2'-ANHYDROARABINOSYLTHYMINE DERIVATIVE
Document Type and Number:
Japanese Patent JP3259191
Kind Code:
B2
Abstract:

PURPOSE: To obtain a compound simply and in high yield useful as an antiviral agent by reacting a specific arabinoaminooxazoline with an α- bromomethylacrylic ester and subjecting the reaction product to ring closure reaction with potassium t-butoxide.
CONSTITUTION: Arabinoaminooxazoline of formula I is reacted with an α- bromomethylacrylic acid of formula II (R is methyl or ethyl) to give an adduct of arabinoaminooxazoline-α-bromomethylacrylic ester of formula III and then the adduct is subjected to ring closure with potassium t-butoxide to give 2,2'- anhydroarabinosylthymine of formula TV and arabinosylthymine of formula V or the adduct of formula III is subjected to ring closure with sodium methoxide to give 2,2'-anhydro-5,6-dihydrouridine of formula VI, from which a 2,2'-anhydroarabinosylthymine derivative useful as an antiviral agent is obtained in high yield.


Inventors:
Sawai, Hiroaki
Hayashi, Shuichi
Iwatsuki, Takashi
Sekiguchi, Sumie
Application Number:
JP1992000269764
Publication Date:
February 25, 2002
Filing Date:
September 11, 1992
Export Citation:
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Assignee:
Sawai, Hiroaki
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61P31/12; C07H9/06; C07H19/09; (IPC1-7): C07H19/09; C07H9/06
Attorney, Agent or Firm:
萼 経夫 (外2名)