Title:
アルホルモテロールの合成方法
Document Type and Number:
Japanese Patent JP2011523658
Kind Code:
A
Abstract:
The present invention provides a process for preparing a compound of formula (VI) or a salt thereof, the process comprising: (i) reacting 4-methoxyphenyl acetone with an amine of formula (VIII) under conditions of reductive amination to produce a compound of formula (II) or a salt thereof, wherein there is no isolation of an imine intermediate formed during the reductive amination; (ii) condensing the compound (II) or the acid addition salt thereof with an α-haloketone of formula (III) to produce the compound of formula (IV); (iii) reducing the compound (IV) to a compound of formula (V); and (iv) reducing the compound (V) to the compound of formula (VI), wherein the reduction is carried out in the presence of either (1) a hydrogen donating compound in the presence of a hydrogen transfer catalyst; or (2) ammonium formate using a hydrogenation catalyst, wherein R1 and R2 are independently optionally substituted arylalkyl, and Hal is selected from chloro or bromo.
Inventors:
Baman Baishalui Hardanebical
Mangeshu Plabfu
Dohar Marajer Ramachandra Rao
Rajendra Narayan Rao Cancan
Mangeshu Plabfu
Dohar Marajer Ramachandra Rao
Rajendra Narayan Rao Cancan
Application Number:
JP2011512193A
Publication Date:
August 18, 2011
Filing Date:
June 02, 2009
Export Citation:
Assignee:
Shipra Limited
International Classes:
C07C213/02; A61K31/167; C07C217/86; C07C231/02; C07C231/18; C07C233/03
Domestic Patent References:
| JPH0426661A | 1992-01-29 | |||
| JP2000239237A | 2000-09-05 | |||
| JP2002255910A | 2002-09-11 | |||
| JPH08505646A | 1996-06-18 | |||
| JP2001503772A | 2001-03-21 | |||
| JP2002518468A | 2002-06-25 |
Attorney, Agent or Firm:
Toru Ishikawa