Title:
METHOD FOR SYNTHESIZING CHIRAL KYNURENINE COMPOUNDS
Document Type and Number:
Japanese Patent JP2018139608
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for synthesizing chiral kynurenine and related compounds at high chemical and chiral purity which is suitable for large scale production.SOLUTION: The method involves the use of chloroacetonitrile in the presence of aluminum trihalide and boron trihalide to obtain an acylated aniline compound, the use of acetamide diethyl malonate to alkylate the acylated aniline compound to obtain a diethyl ester compound, the removal of a carboxyl group from the diethyl ester compound to obtain an acylated kynurenine compound, and the decomposition of the acylated kynurenine compound using an enzyme.SELECTED DRAWING: None
Inventors:
STEFAN ABELE
KLAUS LAUE
ROLAND A BREITENMOSER
KLAUS LAUE
ROLAND A BREITENMOSER
Application Number:
JP2018093249A
Publication Date:
September 13, 2018
Filing Date:
May 14, 2018
Export Citation:
Assignee:
VISTAGEN THERAPEUTICS INC
International Classes:
C12P41/00; C07C221/00; C07C225/22
Attorney, Agent or Firm:
Asamura patent office