Title:
METHOD OF SYNTHESIZING OXIDIZED PHOSPHOLIPID AND PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS
Document Type and Number:
Japanese Patent JP2012149075
Kind Code:
A
Abstract:
To provided a method of synthesizing an oxidized phospholipid.
The method includes: (a) providing a phospholipid backbone including two fatty acid side chains, wherein at least one of the fatty acid side chains is a mono-unsaturated fatty acid; and (b) oxidizing the double bond of the mono-unsaturated fatty acid to thereby generate the oxidized phospholipid.
Inventors:
HARATS DROR
GEORGE JACOB
HALPERIN GIDEON
GEORGE JACOB
HALPERIN GIDEON
Application Number:
JP2012060309A
Publication Date:
August 09, 2012
Filing Date:
March 16, 2012
Export Citation:
Assignee:
VASCULAR BIOGENICS LTD
International Classes:
A61K45/06; A61K31/075; C07F9/10; A61K31/08; A61K31/11; A61K31/19; A61K31/20; A61K31/215; A61K31/24; A61K31/6615; A61K31/685; A61P9/08; A61P9/10; A61P41/00; C07C43/178
Other References:
JPN6013042542; Ｉｔａｂｅ Ｈ．， Ｓｕｚｕｋｉ Ｋ．， Ｈｏｓｏｙａ Ｒ．， Ｍｏｒｉ Ｍ．， Ｈｉｇａｓｈｉ Ｙ．， Ｆｕｊｉｍｏｔｏ Ｙ．， Ｔａｋａｎｏ Ｔ．: 'Ｐｒｅｐａｒａｔｉｏｎ ｏｆ Ｒａｄｉｏａｃｔｉｖｅ Ａｌｄｅｈｙｄｅ-Ｃｏｎｔａｉｎｉｎｇ Ｐｈｏｓｐｈａｔｉｄｉｌｃｈｏｌｉｎｅ' Ａｎａｌｙｔｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ２８５, 20001001, １５１-１５５
JPN6013042545; Ｉｔａｂｅ Ｈ．， Ｙａｍａｍｏｔｏ Ｈ．， Ｓｕｚｕｋｉ Ｍ．， Ｋａｗａｉ Ｙ．， Ｎａｋａｇａｗａ Ｙ．， Ｓｕｚｕｋｉ Ａ．， Ｉｍａｎａｋａ Ｔ．， Ｔａｋａｎｏ Ｔ．: 'Ｏｘｉｄｉｚｅｄ Ｐｈｏｓｐｈａｔｉｄｉｌｃｈｏｌｉｎｅｓ Ｔｈａｔ Ｍｏｄｉｆｙ Ｐｒｏｔｅｉｎｓ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ ２７１, 1996, ３３２０８-３３２１７
JPN6013042545; Ｉｔａｂｅ Ｈ．， Ｙａｍａｍｏｔｏ Ｈ．， Ｓｕｚｕｋｉ Ｍ．， Ｋａｗａｉ Ｙ．， Ｎａｋａｇａｗａ Ｙ．， Ｓｕｚｕｋｉ Ａ．， Ｉｍａｎａｋａ Ｔ．， Ｔａｋａｎｏ Ｔ．: 'Ｏｘｉｄｉｚｅｄ Ｐｈｏｓｐｈａｔｉｄｉｌｃｈｏｌｉｎｅｓ Ｔｈａｔ Ｍｏｄｉｆｙ Ｐｒｏｔｅｉｎｓ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ ２７１, 1996, ３３２０８-３３２１７
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano
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