To analyze comparative hybridization data based on an array.
Embodiments of the present invention include methods and systems for the analysis of comparative genomic hybridization(CGH) data, including OGH data obtained from micro-array based experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for the CGH data and methods for identifying sets of one or more continuous chromosomal DNA subsequences that are amplified or deleted in cells from particular tissue samples. When combined with well-designed micro-array based experimental systems, method embodiments of the present invention provide markedly increased quantitative precision in the identification of chromosomal abnormalities, including amplified and deleted DNA subsequences based on the CGH data.
YAKHINI ZOHAR H
KINCAID ROBERT H
Arihara Koichi
Matsushima Tetsuo