Title:
METHOD AND SYSTEM FOR PROFILING BIOLOGICAL SYSTEM
Document Type and Number:
Japanese Patent JP2009133867
Kind Code:
A
Abstract:
To provide a method and system for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples.
This method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation. A technology platform is also provided for facilitating the discernment of similarities, differences, and/or correlations not only between the single biomolecular components in samples or biological systems, but also between patterns of the biomolecular components of the single biomolecular component type.
Inventors:
VAN DER GREEF JAN
Application Number:
JP2009047371A
Publication Date:
June 18, 2009
Filing Date:
February 27, 2009
Export Citation:
Assignee:
BG MEDICINE INC
International Classes:
G01N27/62; G01N33/50; G16B40/10; B01J20/283; C12Q1/02; C12Q1/68; G01N30/26; G01N30/34; G01N30/72; G01N30/88; G01N31/00; G01N33/15; G01N33/48; G01N33/53; G01R33/465
Domestic Patent References:
| JPH0815247A | 1996-01-19 | |||
| JPH11502935A | 1999-03-09 |
Foreign References:
| WO2000047992A1 | 2000-08-17 | |||
| WO1999050437A1 | 1999-10-07 | |||
| US20020095260A1 | 2002-07-18 |
Other References:
TATE A.R. ET AL.: ""Investigation of the Metabolite Variation in Control Rat Urine Using 1H NMR Spectroscopy."", ANALYTICAL BIOCHEMISTRY, vol. 291, no. 1, JPN7008006681, 11 July 2000 (2000-07-11), pages 17 - 26, ISSN: 0002188906
HOLMES E. ET AL.: ""Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids."", CHEM. RES. TOXICOL., vol. 13, no. 6, JPN7008006682, 20 December 1999 (1999-12-20), pages 471 - 478, ISSN: 0002188907
""'Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimul", XENOBIOTICA, vol. 29, no. 11, JPN7008006683, 5 July 1999 (1999-07-05), pages 1181 - 1189, ISSN: 0002188908
GRIBBESTAD I.S. ET AL.: ""Metabolite Composition in Breast Tumors Examined by Proton Nuclear Magnetic Resonance Spectroscopy.", ANTICANCER RESEARCH, vol. Vol.19, No.3A, JPN7008006684, 26 February 1999 (1999-02-26), ISSN: 0002188909
HOLMES E. ET AL.: ""Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids."", CHEM. RES. TOXICOL., vol. 13, no. 6, JPN7008006682, 20 December 1999 (1999-12-20), pages 471 - 478, ISSN: 0002188907
""'Metabonomics':understanding the metabolic responses of living systems to pathophysiological stimul", XENOBIOTICA, vol. 29, no. 11, JPN7008006683, 5 July 1999 (1999-07-05), pages 1181 - 1189, ISSN: 0002188908
GRIBBESTAD I.S. ET AL.: ""Metabolite Composition in Breast Tumors Examined by Proton Nuclear Magnetic Resonance Spectroscopy.", ANTICANCER RESEARCH, vol. Vol.19, No.3A, JPN7008006684, 26 February 1999 (1999-02-26), ISSN: 0002188909
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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