Title:
METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING MATERIAL MAYTANSINOID CONJUGATES LINKED VIA NON-CLEAVABLE LINKER, CONJUGATES, AND METHODS OF MAKING CONJUGATES
Document Type and Number:
Japanese Patent JP2019142864
Kind Code:
A
Abstract:
To provide a method for targeting maytansinoids to a selected cell population.SOLUTION: A method comprises contacting a cell population or tissue suspected of containing a selected cell population with a cell-binding material maytansinoid conjugate, wherein: one or more maytansinoids are covalently linked to the cell-binding material via a non-cleavable linker (e.g. SMCC expressed by the following formula); and the cell-binding material binds to cells of the selected cell population.SELECTED DRAWING: None
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Inventors:
STEEVES RITA
LUTZ ROBERT
CHARI RAVI
XIE HONGSHENG
KOVTUN YELENA
LUTZ ROBERT
CHARI RAVI
XIE HONGSHENG
KOVTUN YELENA
Application Number:
JP2019038151A
Publication Date:
August 29, 2019
Filing Date:
March 04, 2019
Export Citation:
Assignee:
IMMUNOGEN INC
International Classes:
A61K31/537; A61K39/395; A61K47/54; A61K47/64; A61K47/68; A61P1/04; A61P1/18; A61P3/10; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P19/02; A61P25/00; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P33/04; A61P35/00; A61P35/02; A61P37/02; A61P37/06; C07C55/14; C07D498/18
Domestic Patent References:
| JP2003528034A | 2003-09-24 | |||
| JPH1084959A | 1998-04-07 |
Foreign References:
| WO2002098883A1 | 2002-12-12 |
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Reiko Izumiya
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Reiko Izumiya