METHOD OF TREATING MALIGNANCY IN SUBJECT VIA DIRECT PICORNAVIRAL-MEDIATED ONCOLYSIS

Japanese Patent JP2012046489

A

To provide methods for treatment of abnormal cells such as cancer cells in a mammal, and pharmaceutical compositions.

There are provided the methods for treatment of abnormal cells in the mammal with virus selected from echoviruses and modified forms and combination thereof, which recognize α₂β₁ for infectivity of the cells, and pharmaceutical compositions. The virus is preferably selected from echovirus serovar, and modified forms thereof. The modified echovirus preferably has a modified form selected from the group consisting of EV1, EV7, EV8 and EV22.

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SHAFREN DARREN R

JP2011151340A

March 08, 2012

July 08, 2011

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VIRALYTICS LTD

A61K35/76; A61K48/00; A61P1/00; A61P1/18; A61P13/08; A61P15/00; A61P17/00; A61P35/00; A61P37/04; A61P43/00; C12N7/00; C12Q1/70; G01N33/15; G01N33/50; C12N15/09

JPN6013022208; Ｖｉｒｏｌｏｇｙ Ｖｏｌ．２３５, 1997, ｐ．２９３-３０１
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JPN6013022212; Ｊｏｕｒｎａｌ　ｏｆ　Ｖｉｒｏｌｏｇｙ Ｖｏｌ．７６，　Ｎｏ．４, 200202, ｐ．１８５６-１８６５
JPN6013022214; Ｓｃｉｅｎｃｅ Ｖｏｌ．２５５, 1992, ｐ．１７１８-１７２０
JPN6013022217; Ｖｉｒｏｌｏｇｙ Ｖｏｌ．２５０, 1998, ｐ．８５-９３
JPN6013022219; Ｖｉｒｏｌｏｇｙ Ｖｏｌ．２７６, 2000, ｐ．２４３-２５０
JPN6013022221; Ｃｅｌｌ．　Ｓｉｇｎａｌ． Ｖｏｌ．１０，　Ｎｏ．１, 1998, ｐ．５５-６３

Nobuaki Kazehaya
Noriko Asano

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