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Title:
METHOD FOR TREATING TUMOR USING NORDIHYDROGUAIARETIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2009242438
Kind Code:
A
Abstract:

To provide a compound and a composition for use in the treatment of cancerous and noncancerous tumors in animals, particularly in mammals, and most particularly in human.

Provided is the use of nordihydroguaiaretic acid derivatives, especially the use of the derivatives comprising substitutes of natural amino acids for treatment of tumors and viral infections. Provided is the compound and composition for treatment of cancerous and noncancerous tumors in animals, particularly in mammals (most particularly in humans). A new nordihydroguaiaretic acid derivative which inhibits proliferation of tumors, is provided according to the situation. The nordihydroguaiaretic acid derivative is the compound represented by formula (I), wherein R1, R2, R3 and R4 are each independently an -OH group, -OCH3 group, -O(C=O)CH3, or amino acid residue, but each is not an -OH group at the same time.


Inventors:
HUANG RU CHIH C
HELLER JONATHAN D
CHANG CHIH-CHUAN
Application Number:
JP2009177106A
Publication Date:
October 22, 2009
Filing Date:
July 29, 2009
Export Citation:
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Assignee:
UNIV JOHNS HOPKINS
International Classes:
A61K31/09; A61K47/20; A61K31/075; A61K31/197; A61K31/198; A61K31/22; A61K31/223; A61K31/225; A61K31/401; A61K31/405; A61K31/417; A61P31/12; A61P31/14; A61P31/18; A61P31/22; A61P35/00; A61P43/00; C07C43/20; C07C69/12
Domestic Patent References:
JPS6479112A1989-03-24
Foreign References:
WO2001028494A22001-04-26
Other References:
JPN6009003852; Jodi Craigo, Michelle Callahan, Ru Chih C. Huang, Angelo L. DeLucia: 'Inhibition of human papillomavirus type 16 gene expression by nordihydroguaiaretic acid plant lignan' Antiviral Research Vol. 47, No. 1, 2000, p. 19-28
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita