Title:
METHOD OF USING DEATH RECEPTOR AGONIST AND EGFR INHIBITOR
Document Type and Number:
Japanese Patent JP2012229237
Kind Code:
A
Abstract:
To provide a drug for treating pathological condition of cancer or the like.
There are provided a pharmaceutical preparation containing death receptor ligands including Apo-2 ligand/TRAIL polypeptides or death receptor antibodies, and EGFR inhibitors including a quinazoline derivative, and methods for using the same. The death receptor antibodies are preferably DR5 antibodies and DR4 antibodies, and the quinazoline derivative is TarcevaTM [N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine]. Methods for using in combination with them are provided.
Inventors:
ASHKENAZI AVI J
Application Number:
JP2012150088A
Publication Date:
November 22, 2012
Filing Date:
July 04, 2012
Export Citation:
Assignee:
GENENTECH INC
International Classes:
A61K45/06; A61K31/517; A61K38/00; A61K39/395; A61K47/48; A61P35/00; A61P43/00; C12N5/07; C12N5/09; C07K16/28; C07K16/46
Other References:
JPN7011002996; Ｂｒａｉｎ Ｐａｔｈｏｌｏｇｙ Ｖｏｌ．１２， Ｎｏ．１, 2002, ｐ．１２-２０
JPN6011043411; 最新医学 第５８巻，第１２号, 2003, ｐ．２７８６-２７９２
JPN6011043412; Ｓｕｒｇｅｒｙ Ｆｒｏｎｔｉｅｒ 第１０巻，第４号, 2003, ｐ．３４５-３５３
JPN6011043413; 癌と化学療法 第３２巻，第１号, 200501, ｐ．１５-１８
JPN6011043411; 最新医学 第５８巻，第１２号, 2003, ｐ．２７８６-２７９２
JPN6011043412; Ｓｕｒｇｅｒｙ Ｆｒｏｎｔｉｅｒ 第１０巻，第４号, 2003, ｐ．３４５-３５３
JPN6011043413; 癌と化学療法 第３２巻，第１号, 200501, ｐ．１５-１８
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori
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