Title:
METHOD FOR USING (R)-ISOFLURANE AND (R)-DESFLURANE AND COMPOSITION
Document Type and Number:
Japanese Patent JPH05186338
Kind Code:
A
Abstract:
PURPOSE: To diminish adverse effects caused by a high dose of racemic isoflurane or desflurane which is an anesthetic for inducing and maintaining anesthesia and which is administered by inhalation. CONSTITUTION: This method of inducing and maintaining anesthesia comprises administering by inhalation to a warm blooded animal including a mammal in need of anesthesia an amount sufficient to induce and maintain anesthesia but insufficient to cause adverse effects, of (R)-isoflurane or (R)-desflurane substantially not containing (S)-stereoisomer, while diminishing the concomitant liability of adverse effects, such as hypoventilation, low blood pressure and arrhythmia, associated with the administration. The inhalation concentration of the anesthetic (R-isomer) administered for inducing the anesthesia is 0.5-5.0%, 0.5-2.0%, when nitrous oxide is simultaneously administered, or 0.5-3.5%, when oxygen is simultaneously administered. Since the (R)-isoflurane or (R)-desflurane exhibits the anesthetic activity in a lower concentration and at a lower dose than the corresponding racemic mixture, adverse effects are little.
Inventors:
JIEEMUSU DABURIYUU YANGU
SUTEIIBUN BURANDO
SUTEIIBUN BURANDO
Application Number:
JP31704691A
Publication Date:
July 27, 1993
Filing Date:
November 29, 1991
Export Citation:
Assignee:
SEPRACOR INC
International Classes:
A61K31/02; A61K31/08; A61P23/00; A61P25/20; A61P43/00; (IPC1-7): A61K31/08
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)