Title:
腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
Document Type and Number:
Japanese Patent JP2013510321
Kind Code:
A
Abstract:
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect soluble Transmembrane glycoprotein NMB, and optionally further a kidney injury marker of C-C motif chemokine 23, Brain-derived neurotrophic factor, Cathepsin S, Transforming growth factor beta-2, Urokinase-type plasminogen activator, Angiopoietin-2, Matrilysin, Carcinoembryonic antigen-related cell adhesion molecule 1, Creatine kinase MB, Insulin, Immunoglobulin M, Immunoglobulin E, Macrophage migration inhibitory factor, Galectin-3, Transforming growth factor beta-3, Heparan sulfate, soluble Cadherin-3, Complement C5, Platelet factor 4, Platelet basic protein, and Stromelysin-2 as diagnostic and prognostic biomarkers in renal injuries.
Inventors:
Underberg, joseph
Grey, jeff
Mcpherson, paul
Nakamura, Kevin
Comp, james, patrick
Grey, jeff
Mcpherson, paul
Nakamura, Kevin
Comp, james, patrick
Application Number:
JP2012538050A
Publication Date:
March 21, 2013
Filing Date:
November 05, 2010
Export Citation:
Assignee:
Astute Medical, Inc.
International Classes:
G01N33/53; C07K14/52
Domestic Patent References:
| JP2003533699A | 2003-11-11 | |||
| JP2006038877A | 2006-02-09 | |||
| JP2007078705A | 2007-03-29 | |||
| JP2003533699A | 2003-11-11 | |||
| JP2006038877A | 2006-02-09 |
Other References:
JPN7014001843; Ｗ． Ｋ． Ｈａｎ ｅｔ ａｌ．: 'Ｕｒｉｎａｒｙ Ｂｉｏｍａｒｋｅｒｓ ｉｎ ｔｈｅ Ｅａｒｌｙ Ｄｅｔｅｃｔｉｏｎ ｏｆ Ａｃｕｔｅ Ｋｉｄｎｅｙ Ｉｎｊｕｒｙ ａｆｔｅｒ Ｃａｒｄｉａｃ Ｓｕｒｇｅｒｙ' Ｃｌｉｎ． Ｊ． Ａｍ． Ｓｏｃ． Ｎｅｐｈｒｏｌｏｇｙ Ｖｏｌ． ４， Ｎｏ． ５, 200905, ｐｐ． ８７３-８８１
JPN7014001844; Ｅ． ＡＪ Ｈｏｓｔｅ: 'ＲＩＦＬＥ ｃｒｉｔｅｒｉａ ｆｏｒ ａｃｕｔｅ ｋｉｄｎｅｙ ｉｎｊｕｒｙ ａｒｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｈｏｓｐｉｔａｌ ｍｏｒｔａｌｉｔｙ ｉｎ ｃｒｉｔｉｃａｌｌｙ ｉｌｌ ｐａｔｉ' Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｖｏｌ． １０， Ｒ７３, 20060512
JPN7014001843; Ｗ． Ｋ． Ｈａｎ ｅｔ ａｌ．: 'Ｕｒｉｎａｒｙ Ｂｉｏｍａｒｋｅｒｓ ｉｎ ｔｈｅ Ｅａｒｌｙ Ｄｅｔｅｃｔｉｏｎ ｏｆ Ａｃｕｔｅ Ｋｉｄｎｅｙ Ｉｎｊｕｒｙ ａｆｔｅｒ Ｃａｒｄｉａｃ Ｓｕｒｇｅｒｙ' Ｃｌｉｎ． Ｊ． Ａｍ． Ｓｏｃ． Ｎｅｐｈｒｏｌｏｇｙ Ｖｏｌ． ４， Ｎｏ． ５, 200905, ｐｐ． ８７３-８８１
JPN7014001844; Ｅ． ＡＪ Ｈｏｓｔｅ: 'ＲＩＦＬＥ ｃｒｉｔｅｒｉａ ｆｏｒ ａｃｕｔｅ ｋｉｄｎｅｙ ｉｎｊｕｒｙ ａｒｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｈｏｓｐｉｔａｌ ｍｏｒｔａｌｉｔｙ ｉｎ ｃｒｉｔｉｃａｌｌｙ ｉｌｌ ｐａｔｉ' Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｖｏｌ． １０， Ｒ７３, 20060512
JPN7014001844; Ｅ． ＡＪ Ｈｏｓｔｅ: 'ＲＩＦＬＥ ｃｒｉｔｅｒｉａ ｆｏｒ ａｃｕｔｅ ｋｉｄｎｅｙ ｉｎｊｕｒｙ ａｒｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｈｏｓｐｉｔａｌ ｍｏｒｔａｌｉｔｙ ｉｎ ｃｒｉｔｉｃａｌｌｙ ｉｌｌ ｐａｔｉ' Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｖｏｌ． １０， Ｒ７３, 20060512
JPN7014001843; Ｗ． Ｋ． Ｈａｎ ｅｔ ａｌ．: 'Ｕｒｉｎａｒｙ Ｂｉｏｍａｒｋｅｒｓ ｉｎ ｔｈｅ Ｅａｒｌｙ Ｄｅｔｅｃｔｉｏｎ ｏｆ Ａｃｕｔｅ Ｋｉｄｎｅｙ Ｉｎｊｕｒｙ ａｆｔｅｒ Ｃａｒｄｉａｃ Ｓｕｒｇｅｒｙ' Ｃｌｉｎ． Ｊ． Ａｍ． Ｓｏｃ． Ｎｅｐｈｒｏｌｏｇｙ Ｖｏｌ． ４， Ｎｏ． ５, 200905, ｐｐ． ８７３-８８１
JPN7014001844; Ｅ． ＡＪ Ｈｏｓｔｅ: 'ＲＩＦＬＥ ｃｒｉｔｅｒｉａ ｆｏｒ ａｃｕｔｅ ｋｉｄｎｅｙ ｉｎｊｕｒｙ ａｒｅ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｈｏｓｐｉｔａｌ ｍｏｒｔａｌｉｔｙ ｉｎ ｃｒｉｔｉｃａｌｌｙ ｉｌｌ ｐａｔｉ' Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｖｏｌ． １０， Ｒ７３, 20060512
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Nao Oda