腎損傷および腎不全の診断および予後診断のための方法ならびに組成物

Japanese Patent JP2013510322

A

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2-microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.

Underberg, joseph
Grey, jeff
Mcpherson, paul
Nakamura, Kevin
Comp, james, patrick

JP2012538053A

March 21, 2013

November 05, 2010

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Astute Medical, Inc.

G01N33/573; C07K14/47

JP2010529458A

2010-08-26

WO2008154238A1

2008-12-18

JPN6014025364; Ｇ．　Ｓｅｎａｔｏｒｓｋｉ　ｅｔ　ａｌ．: 'Ｕｒｉｎｅ　ａｃｔｉｖｉｔｙ　ｏｆ　ｃａｔｈｅｐｓｉｎ　Ｂ，　ｃｏｌｌａｇｅｎａｓｅ　ａｎｄ　ｕｒｉｎｅ　ｅｘｃｒｅｔｉｏｎ　ｏｆ　ＴＧＦ-beta１　ａｎｄ　ｆｉｂｒｏｎｅｃｔｉｎ　ｉｎ　ｍｅｍｂｒａｎ' Ｒｅｓ．　Ｅｘｐ．　Ｍｅｄ． Ｖｏｌ．　１９８, 1998, ｐｐ．　１９９-２０６
JPN7014001845; Ｗ．　Ｋ．　Ｈａｎ　ｅｔ　ａｌ．: 'Ｕｒｉｎａｒｙ　Ｂｉｏｍａｒｋｅｒｓ　ｉｎ　ｔｈｅ　Ｅａｒｌｙ　Ｄｅｔｅｃｔｉｏｎ　ｏｆ　Ａｃｕｔｅ　Ｋｉｄｎｅｙ　Ｉｎｊｕｒｙ　ａｆｔｅｒ　Ｃａｒｄｉａｃ　Ｓｕｒｇｅｒｙ' Ｃｌｉｎ．　Ｊ．　Ａｍ．　Ｓｏｃ．　Ｎｅｐｈｒｏｌｏｇｙ Ｖｏｌ．　４，　Ｎｏ．　５, 200905, ｐｐ．　８７３-８８１
JPN7014001846; ＡＪ　Ｈｏｓｔｅ　ｅｔ　ａｌ．: 'ＲＩＦＬＥ　ｃｒｉｔｅｒｉａ　ｆｏｒ　ａｃｕｔｅ　ｋｉｄｎｅｙ　ｉｎｊｕｒｙ　ａｒｅ　ａｓｓｏｃｉａｔｅｄ　ｗｉｔｈ　ｈｏｓｐｉｔａｌ　ｍｏｒｔａｌｉｔｙ　ｉｎ　ｃｒｉｔｉｃａｌｌｙ　ｉｌｌ　ｐａｔｉ' Ｃｒｉｔｉｃａｌ　Ｃａｒｅ Ｖｏｌ．　１０，　Ｒ７３, 20060512

Ryoichi Takaoka
Nao Oda

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