Title:
針不用の高分子送達のための方法及び組成物
Document Type and Number:
Japanese Patent JP2008515808
Kind Code:
A
Abstract:
Methods and compositions for needleless delivery of macromolecules to the bloodstream of a subject are provided herein. In one aspect, the invention provides a delivery construct, comprising a receptor binding domain, a transcytosis domain, a macromolecule to be delivered to a subject, and a cleavable linker. In certain aspects, the cleavable linker can be cleavable by an enzyme present in higher concentration at or near the basal-lateral membrane of a polarized epithelial cell or in the plasma than elsewhere in the body, for example, at the apical side of the polarized epithelial cell. In other aspects, the invention provides nucleic acids encoding delivery constructs of the invention, kits comprising delivery constructs of the invention, cells expressing delivery constructs of the invention, and methods of using delivery constructs of the invention.
Inventors:
Randalluru Jay.
Application Number:
JP2007534904A
Publication Date:
May 15, 2008
Filing Date:
October 04, 2005
Export Citation:
Assignee:
Trinity Biosystems, Inc.
International Classes:
A61K47/48; A61K38/00; A61K38/21; A61K38/22; A61K38/27; A61K38/28; A61K38/43; A61K39/395; A61K47/42; A61K48/00; A61P5/06; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C07K5/08; C07K5/103; C07K14/21
Domestic Patent References:
| JP2003512441A | 2003-04-02 |
Attorney, Agent or Firm:
Toru Ishikawa