Title:
(-)-ヒドロキシクエン酸を安定して制御送達するための方法および組成物
Document Type and Number:
Japanese Patent JP2007502331
Kind Code:
A
Abstract:
The present invention provides stable encapsulated (−)-hydroxycitric acid (HCA)-containing compositions and methods of making the same. A method is provided by which the hygroscopic salts of HCA in their relatively pure and active forms, including especially the potassium salt, but also including the sodium salt, are rendered non-hygroscopic and stable (that is, not prone to lactonization, not readily subject to attachment to ligands which inhibit absorption or lead to excretion, and so forth) such that these HCA salts might be included in dry delivery formats, liquid delivery and in controlled-release vehicles. The nonhygroscopic salts of HCA and its derivatives likewise may be protected against acid degradation, lactonization and undesirable ligand binding when exposed to acidic environments or other challenging conditions. The method taught herein can be employed to reduce the polar/ionic qualities of HCA salts and derivatives when presented to the intestinal lumen to provide advantages in absorption.
Inventors:
Clau Atre Dallas El.
Dan James M.
Dan James M.
Application Number:
JP2006533531A
Publication Date:
February 08, 2007
Filing Date:
May 28, 2004
Export Citation:
Assignee:
Grucon Technologies Group LLC
International Classes:
A61K31/194; A61K9/08; A61K9/14; A61K9/20; A61K9/48; A61K31/191; A61K47/04; A61K47/12; A61K47/14; A61K47/18; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61K47/44; A61P3/04; A61P3/06; A61K9/16; A61K9/50
Foreign References:
| WO2003013474A1 | 2003-02-20 | |||
| US6447807B1 | 2002-09-10 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi