Title:
持続性新生児肺高血圧症をアルアルキルエステルソフト薬物を使用して治療するための方法および組成物
Document Type and Number:
Japanese Patent JP2006508984
Kind Code:
A
Abstract:
A method and compositions for treating persistent pulmonary hypertension in human newborns that deploys an intravenous infusion of a modified drug formed by adding one or more of a predetermined chemical arrangement to an efficacious parent drug compound so as to retain efficacy while re-directing a preferred route and rate of the parent drug compound's metabolism to an inactive or very weakly active and non-toxic metabolite are disclosed. The chemical arrangement is phi-R-X-R'; wherein phi is a phenyl, substituted aryl or heteroaryl system that is already present in the parent drug compound or is specifically added to the parent drug compound via a metabolically stable connection; R is an alkyl or alkene containing chain either branched or unbranched from 0 to 10 carbons that is already present in the parent drug compound or is added to the parent drug compound via a metabolically stable connection to phi; X is a carboxyl, sulfoxyl or phosphatyl function that is specifically added to the parent drug compound via a metabolically stable connection to R; and, R' is an added alkyl, alkenyl or aralkyl group either branched or unbranched containing from 1 to 10 carbons, or is a structural element already present as an inherent portion of the parent drug compound.
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Inventors:
Airhart, Paul W
Aousmany, Moustafa M
Aousmany, Moustafa M
Application Number:
JP2004553810A
Publication Date:
March 16, 2006
Filing Date:
November 17, 2003
Export Citation:
Assignee:
The University of Toledo
International Classes:
A61K45/00; C07D499/68; A61K31/185; A61K31/195; A61K31/216; A61K31/235; A61K31/24; A61K31/245; A61K31/277; A61K31/401; A61K31/4025; A61K31/405; A61K31/4164; A61K31/4166; A61K31/4168; A61K31/421; A61K31/426; A61K31/43; A61K31/4422; A61K31/454; A61K31/46; A61K31/517; A61K31/519; A61K31/522; A61K31/55; A61K31/58; A61K31/65; A61K31/66; A61K47/48; A61P9/06; A61P9/12; A61P17/02; A61P17/06; A61P25/02; A61P29/00; A61P31/10; A61P35/00; A61P43/00; C07C217/40; C07C219/10; C07C219/14; C07C229/60; C07C237/04; C07D207/16; C07D209/26; C07D209/28; C07D211/90; C07D223/22; C07D233/06; C07D233/26; C07D233/50; C07D233/76; C07D261/16; C07D277/20; C07D277/56; C07D295/14; C07D401/06; C07D405/12; C07D451/06; C07D451/10; C07D473/06; C07D475/08; C07D501/22; C07J43/00; A61K47/46
Foreign References:
| WO2001087299A1 | 2001-11-22 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Nakamura Yoshiya
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Nakamura Yoshiya