Title:
低血漿レプチンレベルに関連した障害治療のために、免疫調節性化合物を用いる方法、及びそれを用いた組成物
Document Type and Number:
Japanese Patent JP2009507836
Kind Code:
A
Abstract:
Methods of treating, preventing and/or managing disorders associated with low plasma leptin levels are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active agent.
Inventors:
Dominique bergerle
Quile Chan
Helen Bradoy
Quile Chan
Helen Bradoy
Application Number:
JP2008530025A
Publication Date:
February 26, 2009
Filing Date:
September 12, 2006
Export Citation:
Assignee:
CELGENE CORPORATION
International Classes:
A61K45/00; A61K31/454; A61K38/24; A61K38/28; A61K45/06; A61P1/14; A61P1/16; A61P3/00; A61P3/06; A61P5/00; A61P5/14; A61P5/38; A61P7/08; A61P15/08; A61P15/12; A61P17/00; A61P17/14; A61P19/08; A61P37/02; C12N15/09; C12Q1/68
Foreign References:
| WO2004037199A2 | 2004-05-06 | |||
| WO2003073981A2 | 2003-09-12 | |||
| WO1995024891A1 | 1995-09-21 |
Other References:
HASLETT PA: "Anticytokine approaches to the treatment of anorexia and cachexia.", SEMIN ONCOL., vol. Vol.25 no.2 Suppl. 6, JPN6012004406, April 1998 (1998-04-01), pages 53 - 57, ISSN: 0002132989
TORO R AND BRUERA E: "Anorexia y caquexia en cancer avanzado", ONCOLOGIA, vol. 23, no. 4, JPN6012004408, 2000, pages 21 - 28, ISSN: 0002132990
三木 隆治ら: "自然発症２型糖尿病モデルＳＤＴラットに対するサリドマイド投与の効果", 第４８回日本糖尿病学会年次学術集会予稿集, JPN6012004400, 25 April 2005 (2005-04-25), pages 175, ISSN: 0002132991
TEO SK: "Properties of thalidomide and its analogues: implications for anticancer therapy.", AAPS J., vol. 7, no. 1, JPN6012004401, 22 May 2005 (2005-05-22), pages 14 - 19, ISSN: 0002132992
YAMAGUCHI M ET AL.: "Autocrine inhibition of leptin production by tumor necrosis factor-alpha (TNF-alpha) through TNF-alp", BIOCHEM BIOPHYS RES COMMUN., vol. 244, no. 1, JPN6012004404, 6 March 1998 (1998-03-06), pages 30 - 34, ISSN: 0002132993
KRISTENSEN K ET AL.: "Regulation of leptin by steroid hormones in rat adipose tissue.", BIOCHEM BIOPHYS RES COMMUN., vol. 259, no. 3, JPN6012004403, 16 June 1999 (1999-06-16), pages 624 - 630, ISSN: 0002132994
TORO R AND BRUERA E: "Anorexia y caquexia en cancer avanzado", ONCOLOGIA, vol. 23, no. 4, JPN6012004408, 2000, pages 21 - 28, ISSN: 0002132990
三木 隆治ら: "自然発症２型糖尿病モデルＳＤＴラットに対するサリドマイド投与の効果", 第４８回日本糖尿病学会年次学術集会予稿集, JPN6012004400, 25 April 2005 (2005-04-25), pages 175, ISSN: 0002132991
TEO SK: "Properties of thalidomide and its analogues: implications for anticancer therapy.", AAPS J., vol. 7, no. 1, JPN6012004401, 22 May 2005 (2005-05-22), pages 14 - 19, ISSN: 0002132992
YAMAGUCHI M ET AL.: "Autocrine inhibition of leptin production by tumor necrosis factor-alpha (TNF-alpha) through TNF-alp", BIOCHEM BIOPHYS RES COMMUN., vol. 244, no. 1, JPN6012004404, 6 March 1998 (1998-03-06), pages 30 - 34, ISSN: 0002132993
KRISTENSEN K ET AL.: "Regulation of leptin by steroid hormones in rat adipose tissue.", BIOCHEM BIOPHYS RES COMMUN., vol. 259, no. 3, JPN6012004403, 16 June 1999 (1999-06-16), pages 624 - 630, ISSN: 0002132994
Attorney, Agent or Firm:
Toru Ishikawa