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Title:
RGS21活性の調節物質を同定するための方法、RGS21調節物質を含む組成物、および味覚を調節するためのその使用方法
Document Type and Number:
Japanese Patent JP2009544330
Kind Code:
A
Abstract:
The present invention provides methods for identifying compounds that selectively and specifically modulate RGS21 gene expression, RGS21 protein expression, and/or the interaction of RGS21 with G proteins in taste signal transduction. In particular, the present invention provides methods for identifying modulators of RGS21 activity for enhancing sweet taste, or other taste perception. Compositions comprising modulators of RGS21 activity for modulating taste signaling transduction are also provided.

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Inventors:
Radha Krishana, Harish
Brown, Michael, Dee.
DuBois, Grant, Yi.
Application Number:
JP2009522004A
Publication Date:
December 17, 2009
Filing Date:
July 26, 2007
Export Citation:
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Assignee:
THE COCA-COLA COMPANY
International Classes:
C12Q1/02; A61K45/00; A61P43/00; C12Q1/42; C12Q1/48; G01N33/15; G01N33/50; C07K14/47; C12N15/09
Foreign References:
WO2003016345A12003-02-27
WO2003070892A22003-08-28
WO2003016345A12003-02-27
Other References:
JPN7013000117; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．１９, 2004, ｐ．１５３５-１５４４
JPN6014007924; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２７６，　Ｎｏ．２３, 2001, ｐ．２０１６０-２０１６６
JPN7013000117; Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｎｅｕｒｏｓｃｉｅｎｃｅ Ｖｏｌ．１９, 2004, ｐ．１５３５-１５４４
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki



 
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