Title:
治療免疫細胞の有効性を改良するための方法
Document Type and Number:
Japanese Patent JP6895380
Kind Code:
B2
Abstract:
The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor - CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.
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Inventors:
Campana, Dario
Kamiya, Takahiro
Kamiya, Takahiro
Application Number:
JP2017541243A
Publication Date:
June 30, 2021
Filing Date:
February 05, 2016
Export Citation:
Assignee:
NATIONAL UNIVERSITY OF SINGAPORE
International Classes:
C12N5/10; A61K35/12; A61K35/17; A61P35/00; C07K16/28; C07K19/00; C12N5/078; C12N15/13; C12N15/62
Domestic Patent References:
| JP2014507118A |
Foreign References:
| US20060034834 | ||||
| WO2016102965A1 |
Other References:
Nat. Biotechnol., 2013, Vol.31, No.1, p.71-75
Blood, 2014, Vol.124, No.7, p.1081-1088
Mol. Ther., 2009, Vol.17, No.8, p.1453-1464
ウイルス, 2004, Vol.54, No.2, p.153-160
J. Cell. Mol. Med., 2007, Vol.11, No.1, p.54-70
Cancer Immunol. Res., 2013, Vol.1, No.1, p.43-53
BSGT Abstracts, 2012, p.A15 (P023)
Blood, 2014, Vol.124, No.7, p.1081-1088
Mol. Ther., 2009, Vol.17, No.8, p.1453-1464
ウイルス, 2004, Vol.54, No.2, p.153-160
J. Cell. Mol. Med., 2007, Vol.11, No.1, p.54-70
Cancer Immunol. Res., 2013, Vol.1, No.1, p.43-53
BSGT Abstracts, 2012, p.A15 (P023)
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito