Title:
免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ切断部位に対する免疫応答を誘発するための方法
Document Type and Number:
Japanese Patent JP5717210
Kind Code:
B2
Abstract:
The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an A²PP epitope spanning the ²-secretase cleavage site of A²PP and a method for inducing an immune response against the ²-secretase cleavage site of A²PP using this immunizing composition. The present invention is also directed to antibodies against the ²-secretase cleavage site of A²PP and their use in a method for inhibiting the formation of amyloid ².
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Inventors:
Solomon, Beka
Application Number:
JP2013107244A
Publication Date:
May 13, 2015
Filing Date:
May 21, 2013
Export Citation:
Assignee:
Ramoth Attel-Aviv University Limited
International Classes:
A61K9/127; A61K39/00; C07K16/18; A61K39/385; A61K39/39; A61K39/395; A61P25/28; A61P37/04; A61P43/00; C07K7/06; C07K14/47; C12N7/00
Foreign References:
| WO2000072880A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Yasuo Yanagibashi
Keiko Ozawa
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Suzuki Otoya
Yasuo Yanagibashi
Keiko Ozawa
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Suzuki Otoya