Title:
中性溶解媒質による過分極薬剤の溶解及びろ過のための方法及び器具
Document Type and Number:
Japanese Patent JP5438359
Kind Code:
B2
Abstract:
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer 14 and transporting it to a receiver 54 is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution 12, transporting the aqueous solution through a fluid path system 44 out of the polarizer, filtering the aqueous solution through a partical size exclusion filter 54 to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial 28 for containing a hyperpolarized imaging agent therein, a dissolution fluid path 36, a delivery fluid path 44 , a particle size exclusion filter 54 ,and a receiver 55 connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
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Inventors:
David Brandon Whit
Andrew Michael Reach
Peter Miller
Eric Terfeyan
Andrew Michael Reach
Peter Miller
Eric Terfeyan
Application Number:
JP2009099478A
Publication Date:
March 12, 2014
Filing Date:
April 16, 2009
Export Citation:
Assignee:
GENERAL ELECTRIC COMPANY
International Classes:
A61B5/055; A61K49/00; G01R33/28
Domestic Patent References:
| JP3682044B2 | ||||
| JP2007021008A | ||||
| JP2004512882A | ||||
| JP2008237910A |
Foreign References:
| WO2008121458A1 | ||||
| US20090263325 | ||||
| EP2112523A1 |
Attorney, Agent or Firm:
Arakawa Satoshi
Hirokazu Ogura
Toshihisa Kurokawa
Hirokazu Ogura
Toshihisa Kurokawa