Title:
アリーロマイシン環類似体を作製するための方法
Document Type and Number:
Japanese Patent JP7041687
Kind Code:
B2
Abstract:
Methods for making an arylomycin ring of formula tor salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.
Inventors:
Petronievic, Philip
Rim, giap-chie
Won, Nicholas
Horn, allen
Hou Yun
Ring, thin
Frances, Gosselin
Rim, giap-chie
Won, Nicholas
Horn, allen
Hou Yun
Ring, thin
Frances, Gosselin
Application Number:
JP2019553110A
Publication Date:
March 24, 2022
Filing Date:
March 26, 2018
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D245/04
Other References:
DUFOUR, J. et al.,INTRAMOLECULAR SUZUKI-MIYAURA REACTION FOR THE TOTAL SAYNTHESIS OF SIGNAL 以下備考,CHEMISTRY A EUROPEAN JOURNAL,2010年07月23日,VOL:16,PAGE(S):10523 - 10534,http://dx.doi.org/10.1002/chem.201000924,PEPTIDASE INHIBITORS, ARYLOMYCINS A2 AND B2
Y.X.TAN et al.,Latetn antibiotics and the pootential of the arylomycins for broad-spectrum antibacterial activity,MEDICINAL CHEMISTRY COMMUNICATIONS,2012年,vol.3, no.8,p.916-925
LIU, J. et al.,SYNTHESIS AND CHARACTERISATION OF THE ARYLOMYCIN LIPOGLYCOPEPTIDE ANTIBIOTICS 以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2011年10月14日,VOL:133,PAGE(S):17869 - 17877,http://dx.doi.org/10.1021/ja207318n,AND THE CRYSTALLOGRAPHIC ANALYSIS OF THEIR COMPLEX WITH SIGNAL PEPTIDASE
SEECHURN, C. C. C. et al.,AIR-STABLE PD(R-ALLYL)L-CL (L = Q-PHOS), P(T-BU)3, ETC.) SYSTEMS FOR C-C/NCOUPLINGS: 以下備考,JOURNAL OF ORGANIC CHEMISTRY,2011年08月08日,VOL:76,PAGE(S):7918 - 7932,http://dx.doi.org/10.1021/jo2013324,INSIGHT INTO THE STRUCTURE-ACTIVITY RELATIONSHIP AND CATALYST ACTIVATION PATHWAY
DEANGELIS, A. J. et al.,GENERATING ACTIVE "L-PD(O)" VIA NEUTRAL OR CATIONIC PI-ALLYLPALLADIUM COMPLEXES 以下備考,JOURNAL OF ORGANIC CHEMISTRY,2015年06月02日,VOL:80,PAGE(S):6794 - 6813,http://dx.doi.org/10.1021/acs.joc.5b01005,FEATURING BIARYL/BIPYRAZOLYLPHOSPHINES: SYNTHETIC, MECHANISTIC, AND STRUCTURE-ACTIVITY 以下省略
Tucker C. ROBERTS et al.,Structural and Initial Biological Analysis of Synthetic Arylomycin A2,J. AM. CHEM. SOC.,2007年,vol.129, no.51,p.15830-15838
Y.X.TAN et al.,Latetn antibiotics and the pootential of the arylomycins for broad-spectrum antibacterial activity,MEDICINAL CHEMISTRY COMMUNICATIONS,2012年,vol.3, no.8,p.916-925
LIU, J. et al.,SYNTHESIS AND CHARACTERISATION OF THE ARYLOMYCIN LIPOGLYCOPEPTIDE ANTIBIOTICS 以下備考,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2011年10月14日,VOL:133,PAGE(S):17869 - 17877,http://dx.doi.org/10.1021/ja207318n,AND THE CRYSTALLOGRAPHIC ANALYSIS OF THEIR COMPLEX WITH SIGNAL PEPTIDASE
SEECHURN, C. C. C. et al.,AIR-STABLE PD(R-ALLYL)L-CL (L = Q-PHOS), P(T-BU)3, ETC.) SYSTEMS FOR C-C/NCOUPLINGS: 以下備考,JOURNAL OF ORGANIC CHEMISTRY,2011年08月08日,VOL:76,PAGE(S):7918 - 7932,http://dx.doi.org/10.1021/jo2013324,INSIGHT INTO THE STRUCTURE-ACTIVITY RELATIONSHIP AND CATALYST ACTIVATION PATHWAY
DEANGELIS, A. J. et al.,GENERATING ACTIVE "L-PD(O)" VIA NEUTRAL OR CATIONIC PI-ALLYLPALLADIUM COMPLEXES 以下備考,JOURNAL OF ORGANIC CHEMISTRY,2015年06月02日,VOL:80,PAGE(S):6794 - 6813,http://dx.doi.org/10.1021/acs.joc.5b01005,FEATURING BIARYL/BIPYRAZOLYLPHOSPHINES: SYNTHETIC, MECHANISTIC, AND STRUCTURE-ACTIVITY 以下省略
Tucker C. ROBERTS et al.,Structural and Initial Biological Analysis of Synthetic Arylomycin A2,J. AM. CHEM. SOC.,2007年,vol.129, no.51,p.15830-15838
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Tsurukuro Toshitaka
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Tsurukuro Toshitaka
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