免疫療法のために同種異系かつ高活性のＴ細胞を操作するための方法

Japanese Patent JP6875124

B2

The present invention relates to methods for developing engineered T-cells for immunotherapy that are non-alloreactive. The present invention relates to methods for modifying T-cells by inactivating both genes encoding T-cell receptor and an immune checkpoint gene to unleash the potential of the immune response. This method involves the use of specific rare cutting endonucleases, in particular TALE-nucleases (TAL effector endonuclease) and polynucleotides encoding such polypeptides, to precisely target a selection of key genes in T-cells, which are available from donors or from culture of primary cells. The invention opens the way to standard and affordable adoptive immunotherapy strategies for treating cancer and viral infections.

WO/2017/034833	METHODS AND MATERIALS FOR EXPANDING ANTIGEN-SPECIFIC T CELLS IN CULTURE
WO/2023/074713	T CELL QUALITY EVALUATION METHOD, AND REAGENT TO BE USED THEREIN
WO/2024/030441	METHODS OF IMPROVING CELLULAR THERAPY WITH ORGANELLE COMPLEXES

Garrett Roman
Goble anies
Gross stephanie
Schiffer-Maniwi Cecil
Poirot Laurent
Charenberg Andrew
Smith julian

JP2016513480A

May 19, 2021

May 13, 2014

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CELLECTIS

C12N5/0783; A61K35/17; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P37/06; C12N5/10

JP2015523064A
JP2015528298A

US20110158957
WO2012068380A2

Blood,119(24)(2012)p.5697-5705
Blood,116(21)(2010)Abstract Number:3766
Curr.Opin.Immunol.,24(5)(2012)p.633-639
Nucleic Acids Res.,39(21)(2011)p.9283-9293
Drug Delivery System,28(1)(2013年1月)p.35-44

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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