Title:
パクリタキセルのサブミクロン粒子を調製するための方法
Document Type and Number:
Japanese Patent JP2007510657
Kind Code:
A
Abstract:
The present invention is concerned with the formation of submicron particles of an antineoplastic agent, particularly paclitaxel, by precipitating the antineoplastic agent in an aqueous medium to form a pre-suspension followed by homogenization. Surfactants with phospholipids conjugated with a water soluble or hydrophilic polymer such as PEG are used as coating for the particles. The particles produced generally have an average particle size of less than about 1000 nm and are not rapidly soluble.
Inventors:
Chowbal, Mahesh
Waring, Jane
Rabino, Barrett E.
Waring, Jane
Rabino, Barrett E.
Application Number:
JP2006538455A
Publication Date:
April 26, 2007
Filing Date:
November 03, 2004
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
International Classes:
A61K31/337; A61K9/10; A61K9/127; A61K9/14; A61K9/19; A61K31/12; A61K31/495; A61K31/496; A61K31/55; A61K31/573; A61K47/24; A61K47/34; A61P35/00; A61K9/16
Domestic Patent References:
| JP2002535242A | 2002-10-22 | |||
| JP2004538249A | 2004-12-24 |
Foreign References:
| WO2002055059A2 | 2002-07-18 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita