Title:
Janusチロシンキナーゼ3(Jak3)を選択的に阻害するための方法
Document Type and Number:
Japanese Patent JP2006514021
Kind Code:
A
Abstract:
Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivative or modified compound, is employed which is capable of selectively inhibiting Jak3 while affecting other protein tyrosine kinase activities to a lesser extent or not at all, to provide beneficial effects such as mitigation of transplant rejection and alleviation of allergic responses with fewer side effects than with conventional immunosuppressive agents.
Inventors:
Kirken, Robert, A.
Khan, Barry, Dee.
Stepkowski, Stanislaw, M.
Preeve, Waldemar
Foct, Isabella
Kocinski, Simon
Khan, Barry, Dee.
Stepkowski, Stanislaw, M.
Preeve, Waldemar
Foct, Isabella
Kocinski, Simon
Application Number:
JP2004559442A
Publication Date:
April 27, 2006
Filing Date:
December 09, 2003
Export Citation:
Assignee:
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
International Classes:
A61K31/132; A61K31/12; A61K31/13; A61K31/21; A61K31/335; A61K31/706; A61K38/00; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P43/00; C07C225/12; C12Q1/02; G01N33/50
Other References:
JPN6010021950, ＤＩＭＭＯＣＫ， ＪＲ ｅｔ ａｌ．, "Ｅｖａｌｕａｔｉｏｎ ｏｆ ｓｏｍｅ Ｍａｎｎｉｃｈ ｂａｓｅｓ ｏｆ ｃｙｃｌｏａｌｋａｎｏｎｅｓ ａｎｄ ｒｅｌａｔｅｄ ｃｏｍｐｏｕｎｄｓ ｆｏｒ ｃｙｔｏｔｏｘｉｃ ａｃｔｉｖｉｔｙ", Ｅｕｒ． Ｊ． Ｍｅｄ． Ｃｈｅｍ．, 1993, Ｖｏｌ．２８， Ｎｏ．４, ｐ．３１３−２２
JPN6010021948, ＤＩＭＭＯＣＫ， ＪＲ ｅｔ ａｌ．, "Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｃｙｔｏｔｏｘｉｃ ｅｖａｌｕａｔｉｏｎ ｏｆ ｓｏｍｅ Ｍａｎｎｉｃｈ ｂａｓｅｓ ｏｆ ａｌｉｃｙｃｌｉｃ ｋｅｔｏｎｅｓ", Ｐｈａｒｍａｚｉｅ, 1995, Ｖｏｌ．５０， Ｎｏ．１, ｐ．６６８−７１
JPN6010021948, ＤＩＭＭＯＣＫ， ＪＲ ｅｔ ａｌ．, "Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｃｙｔｏｔｏｘｉｃ ｅｖａｌｕａｔｉｏｎ ｏｆ ｓｏｍｅ Ｍａｎｎｉｃｈ ｂａｓｅｓ ｏｆ ａｌｉｃｙｃｌｉｃ ｋｅｔｏｎｅｓ", Ｐｈａｒｍａｚｉｅ, 1995, Ｖｏｌ．５０， Ｎｏ．１, ｐ．６６８−７１
Attorney, Agent or Firm:
Hidehiko Okada
Tetsuo Fukuda
Tatsuhiko Inukai
Takashi Ishioka
Mitsuyoshi Hattori
Tetsuo Fukuda
Tatsuhiko Inukai
Takashi Ishioka
Mitsuyoshi Hattori