Title:
バルドキソロンメチルまたはその類似体を使用して内皮機能障害を処置および予防する方法
Document Type and Number:
Japanese Patent JP6564372
Kind Code:
B2
Abstract:
The present invention concerns methods for treating and preventing endothelial dysfunction and related disorders, including, for example, pulmonary arterial hypertension, using bardoxolone methyl or analogs thereof.
Inventors:
Chin Melanie Pay-Hen
Mayer Colin Jay.
Mayer Colin Jay.
Application Number:
JP2016536495A
Publication Date:
August 21, 2019
Filing Date:
August 22, 2014
Export Citation:
Assignee:
Riata Pharmaceuticals, Inc.
International Classes:
A61K31/277; A61K9/10; A61K9/20; A61K9/48; A61K31/137; A61K31/138; A61K31/4166; A61K31/4412; A61K31/4418; A61K31/496; A61K31/4985; A61K31/50; A61K31/506; A61K31/519; A61K31/53; A61K31/554; A61K31/5578; A61K47/32; A61P9/10; A61P9/12; A61P43/00
Domestic Patent References:
| JP2011509941A | ||||
| JP2011518190A | ||||
| JP2010536754A | ||||
| JP2007533760A |
Other References:
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Exp. Lung Res., 2011, Vol.37, No.8, pp.492-499
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PP62 低酸素性肺高血圧に対するNrf2活性化剤の効果,日本呼吸器学会雑誌,2011年,Vol.49増刊号,p.(2011)
Clin Rheumatol,2010年,Vol.22,p.288-293
Lab. Invest., 2006, Vol.86, No.1, pp.62-71
Exp. Lung Res., 2011, Vol.37, No.8, pp.492-499
Am. J. Physiol. Renal Pysiol., 2011, Vol.300, No.5, pp.F1180-F1192
J. Interferon Cytokine res., 2010, Vol.30, No.7, pp.497-508
Proc. Natl. Acad. Sci., 2005, Vol.102, No.12, pp.4584-4589
J. Biol. Chem., 2009, Vol.284, No.46, pp.31579-31586,Online Deta Supplements pp.1-17
Am. J. Respir. Crit. Care Med., 2010, Vol.181, No.12, pp.1285-1293
PP62 低酸素性肺高血圧に対するNrf2活性化剤の効果,日本呼吸器学会雑誌,2011年,Vol.49増刊号,p.(2011)
Clin Rheumatol,2010年,Vol.22,p.288-293
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto