Title:
化学物質の眼刺激性を評価するための方法
Document Type and Number:
Japanese Patent JP7030795
Kind Code:
B2
Abstract:
The present invention concerns an in vitro test for detecting the irritant potential of chemicals combining a corneal cell model with a selection of predictive and qualitative molecular markers to classify compounds into 3 categories, namely irreversible eye damage 21 days after application (category 1), reversible eye damage 21 days after application (category 2) and no irritation (no category). The inventors have thus demonstrated that the response following the action of an irritant substance occurs directly on an in vitro reconstructed corneal epithelium, and that the degree of irritation and the qualification of this irritation of a molecule may be determined by the use of specific biomarkers of eye irritation.
Inventors:
HERVE GROUX
Francois, Kotor
Natalie, Alpe
Birginie, Le Blanc
Francois, Kotor
Natalie, Alpe
Birginie, Le Blanc
Application Number:
JP2019515316A
Publication Date:
March 07, 2022
Filing Date:
September 19, 2017
Export Citation:
Assignee:
IMMUNOSEARCH
International Classes:
C12N15/09; C12Q1/02; C12Q1/6809; G01N33/15; G01N33/50; G01N33/68
Other References:
In Vitro Cell. Dev. Biol.-Animal,2016年,Vol.52,pp.742-748
J. Pharmacol. Toxicol. Methods.,2010年,Vol.61, No.2,pp.136-145
Drug. Deliv. and Transl. Res.,2016年,Vol.6,pp.660-675
J. Pharmacol. Toxicol. Methods.,2010年,Vol.61, No.2,pp.136-145
Drug. Deliv. and Transl. Res.,2016年,Vol.6,pp.660-675
Attorney, Agent or Firm:
Hiroyuki Nagai
Nakamura Yukitaka
Satoru Asakura
Sorimachi Hiroshi
Keiyasu Suzuki
Nakamura Yukitaka
Satoru Asakura
Sorimachi Hiroshi
Keiyasu Suzuki
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