Title:
非小細胞肺癌患者由来のエクソソームＲＮＡ及び無細胞ＤＮＡを使用して血漿中の変異を検出するための方法と組成物
Document Type and Number:
Japanese Patent JP7280823
Kind Code:
B2
Abstract:
The present invention relates generally to methods and kits for detecting one or more biomarkers, such as an Epidermal Growth Factor Receptor (EGFR) mutation, e.g., T790M mutation, L858R mutation, one or more exon19 insertions and/or one or more exon19 deletions in the EGFR gene, in a biological sample to aid in diagnosis, prognosis, monitoring, or therapy selection for a disease such as, for example, cancer. The methods and kits are useful in aiding in diagnosis, prognosis, monitoring, or therapy selection for lung cancer, e.g., non-small cell lung cancer (NSCLC).
Inventors:
Yohann Karl Olof Skoog
Elena Castellanos-Lizaldos
Bashish Thadigotra
Dominic Grimm
Shuan Chang
Way you
Elena Castellanos-Lizaldos
Bashish Thadigotra
Dominic Grimm
Shuan Chang
Way you
Application Number:
JP2019528833A
Publication Date:
May 24, 2023
Filing Date:
November 17, 2017
Export Citation:
Assignee:
Exo Sam Diagnostics, Incorporated
International Classes:
C12Q1/6851; C12Q1/686; C12Q1/6876; G01N33/50
Other References:
Molecular Cancer Therapeutics,2015年,vol.14, issue 12, supplement 2,Abatract B136
Clin Cancer Res,2009年,vol.15, no.8,p.2630-2636
The Journal of Molecular Diagnostics,2013年,vol.15, no.1,p.62-69
Journal of Immunological Methods,2007年,vol.321,p.135-141
European Respiratory Journal,2012年,vol.40, Issue Suppl 56,Abstract No: 7263, Publication No: 1397
Clinical Chemistry,2003年,vol.49, no.10,p.1624-1631
313 Development of a one-step isolation platform for exosomal RNA and circulating cell-free DNA from cancer plasma samples,European Journal of Cancer,2014年,vol.50, suppl.6,p.102,
Clin Cancer Res,2009年,vol.15, no.8,p.2630-2636
The Journal of Molecular Diagnostics,2013年,vol.15, no.1,p.62-69
Journal of Immunological Methods,2007年,vol.321,p.135-141
European Respiratory Journal,2012年,vol.40, Issue Suppl 56,Abstract No: 7263, Publication No: 1397
Clinical Chemistry,2003年,vol.49, no.10,p.1624-1631
313 Development of a one-step isolation platform for exosomal RNA and circulating cell-free DNA from cancer plasma samples,European Journal of Cancer,2014年,vol.50, suppl.6,p.102,
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mihashi
Youichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidenao Tsuda
Shinji Mihashi
Youichi Watanabe
Masaru Nakajima
Ryotaro Takei
Hidenao Tsuda