Title:
治療用細胞組成物の効力を決定するための方法及び組成物
Document Type and Number:
Japanese Patent JP7206212
Kind Code:
B2
Abstract:
This disclosure provides a potency assay for evaluating the potency of facilitating cells and/or alpha beta TCR+ T cells.
Inventors:
Suzanne Tea Ildstad
Andreas Catpodis
Vladimir Senyukov
Margit Yesche
Andreas Catpodis
Vladimir Senyukov
Margit Yesche
Application Number:
JP2019549391A
Publication Date:
January 17, 2023
Filing Date:
March 06, 2018
Export Citation:
Assignee:
Talaris Therapeutics Incorporated
University of Lewisville Research Foundation, Inc.
University of Lewisville Research Foundation, Inc.
International Classes:
C12Q1/06; C07K16/18; G01N33/53; G01N33/536
Domestic Patent References:
| JP2012504970A | ||||
| JP2016527920A |
Other References:
CORNISH, G.H., et al.,"Differential regulation of T-cell growth by IL-2 and IL-15.",BLOOD,2006年,Vol.108, No.2,pp.600-608,DOI: 10.1182/blood-2005-12-4827
SALMOND, R.J., et al.,"MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.",J. IMMUNOL.,2009年,Vol.183,pp.7388-7397,DOI: 10.4049/jimmunol.0902294
JEURINK, P.V., et al.,"T cell responses in fresh and cryopreserved peripheral blood mononuclear cells: kinetics of cell viability, cellular subsets, proliferation, and cytokine production.",CRYOBIOLOGY,Vol.57, No.2,2008年,pp.91-103,DOI: 10.1016/j.cryobiol.2008.06.002
SALMOND, R.J., et al.,"MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.",J. IMMUNOL.,2009年,Vol.183,pp.7388-7397,DOI: 10.4049/jimmunol.0902294
JEURINK, P.V., et al.,"T cell responses in fresh and cryopreserved peripheral blood mononuclear cells: kinetics of cell viability, cellular subsets, proliferation, and cytokine production.",CRYOBIOLOGY,Vol.57, No.2,2008年,pp.91-103,DOI: 10.1016/j.cryobiol.2008.06.002
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe