METHODS AND COMPOSITIONS FOR GENERATING IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS

Title:

METHODS AND COMPOSITIONS FOR GENERATING IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS

Document Type and Number:

Japanese Patent JP2014168479

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters.SOLUTION: Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40 activity. Also provided are nucleic acid compositions comprising sequences coding for chimeric proteins that include an inducible CD40 peptide and an inducible pattern recognition receptor adapter or adapter fragment.

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Inventors:

DAVID SPENCER
NARAYANAN PRIYADHARSHINI

Application Number:

JP2014120212A

Publication Date:

September 18, 2014

Filing Date:

June 11, 2014

Export Citation:

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Assignee:

BAYLOR COLLEGE MEDICINE

International Classes:

C12N5/10; A61K35/76; A61K38/00; A61K39/00; A61K48/00; A61P31/04; A61P35/00; A61P43/00; C12N15/00; C12N15/09

Attorney, Agent or Firm:

Shusaku Yamamoto
Natsuki Morishita

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