Title:
神経変性疾患の同定と治療のための方法及び組成物
Document Type and Number:
Japanese Patent JP2004517634
Kind Code:
A
Abstract:
The present invention relates to Drosophila models of the neurodegenerative disorder spinocerebellar ataxia 1 (SCA-1). In particular, the invention relates to transgenic Drosophila which express normal human ataxin-1 or mutant human ataxin-1 with expanded polyglutamine repeats for SCA-1 therapeutics. The invention further relates to the diagnosis of predispositions to developing SCA-1. The invention further relates to methods of using the transgenic Drosophila to screen for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the identification of modifier genes of the SCA-1 phenotypes produced by overexpression of ataxin-1, for therapeutic and diagnostic uses and for screening for therapeutics of SCA-1 and other neurodegenerative disorders. The invention further relates to the diagnosis of a predisposition to SCA-1 comprising detecting the overexpression of normal ataxin-1.
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Inventors:
Botas, Juan
Zogbi, Fuda
Martinez, Pedro
Fernandez-Funes, Pedro
Nino-Rosares, Maria Laura
Guyoung, Beatrice Dee
Che, Wei Ji
Ruchaku, James
Zogbi, Fuda
Martinez, Pedro
Fernandez-Funes, Pedro
Nino-Rosares, Maria Laura
Guyoung, Beatrice Dee
Che, Wei Ji
Ruchaku, James
Application Number:
JP2002558961A
Publication Date:
June 17, 2004
Filing Date:
October 29, 2001
Export Citation:
Assignee:
BAYLOR COLLEGE OF MEDICINE
International Classes:
A01K67/033; A61K31/7088; A61K31/7105; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P9/00; A61P9/12; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/18; A61P25/28; A61P25/32; A61P27/02; A61P27/06; A61P31/18; A61P35/00; A61P39/04; C07K14/47; C12N15/09; C12N15/12; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): C12N15/09; A01K67/033; A61K31/7088; A61K31/7105; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P9/00; A61P9/12; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/18; A61P25/28; A61P25/32; A61P27/02; A61P27/06; A61P31/18; A61P39/04; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hidekazu Miyoshi
Yasuo Miyoshi
Yasuo Miyoshi