Title:
睡眠を誘導するための方法および組成物
Document Type and Number:
Japanese Patent JP4541166
Kind Code:
B2
Abstract:
Methods and compositions for interacting with the GABAA receptor complex to induce sleep in humans using certain 5 3 alpha -hydroxy-5-reduced steroid derivatives.
Inventors:
Gee, Kelvin W
Run, Nancy Tsusai-Con
Upasani, Rabindra Bee
Hogen Gump, Dake Jay
Paddy, robert
Bolger, Michael Bee
Tahir, Hasan
Run, Nancy Tsusai-Con
Upasani, Rabindra Bee
Hogen Gump, Dake Jay
Paddy, robert
Bolger, Michael Bee
Tahir, Hasan
Application Number:
JP2005006594A
Publication Date:
September 08, 2010
Filing Date:
January 13, 2005
Export Citation:
Assignee:
Euro-Certique S.A.
International Classes:
A61K31/57; A61K31/56; A61K31/565; A61K31/573; A61K31/575; A61K31/58; A61K31/661; A61P25/00; A61P25/20; C07J5/00; C07J7/00; C07J17/00; C07J31/00; C07J33/00; C07J41/00; C07J43/00; C07J51/00
Domestic Patent References:
| JP4266825A | ||||
| JP3500049A |
Foreign References:
| WO1993003732A1 | ||||
| US3274179 | ||||
| WO1993005786A1 |
Other References:
MAJEWSKA, M.D., et al.,Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor,Science,232,pp.1004-1007 (1986)
MELCHIOR, C.L., et al.,Interaction of Pregnanolone and Pregnenolone Sulfate With Ethanol and Pentobarbital,Pharmacol. Biochem. Behavior,42,pp.605-611 (1992)
ARAFAT, E.S., et al.,Sedative and hypnotic effects of oral administration of micronized progesterone may be madiated...,Am. J. Obstet Gynecol.,159,pp.1203-1209 (1988)
GYERMEK, L.,Pregnanolone: A Highly Potnt, Naturally Occuring Hypnotic-Anesthetic Agent,Proc. Soc. Exp. Biol. Med.,125,pp.1058-1062 (1967)
SOYKA, L.F., et al.,DISTRIBUTION AND HEPATIC METABOLISM OF PREGNANOLONE IN THE RAT,Biochem. Pharmacol.,21,pp.657-671 (1972)
MENDELSON, W.B., et al.,Sleep induction by an adrenal steroid in the rat,Psychopharmacology,93,pp.226-229 (1987)
BOWERS, B.J., et al.,Biochemical and Behavioral Effects of Steroids on GABAA Receptor Function in Long-and Short-Sleep...,Brain Res. Bull.,29,pp.57-68 (1992)
MELCHIOR, C.L., et al.,Interaction of Pregnanolone and Pregnenolone Sulfate With Ethanol and Pentobarbital,Pharmacol. Biochem. Behavior,42,pp.605-611 (1992)
ARAFAT, E.S., et al.,Sedative and hypnotic effects of oral administration of micronized progesterone may be madiated...,Am. J. Obstet Gynecol.,159,pp.1203-1209 (1988)
GYERMEK, L.,Pregnanolone: A Highly Potnt, Naturally Occuring Hypnotic-Anesthetic Agent,Proc. Soc. Exp. Biol. Med.,125,pp.1058-1062 (1967)
SOYKA, L.F., et al.,DISTRIBUTION AND HEPATIC METABOLISM OF PREGNANOLONE IN THE RAT,Biochem. Pharmacol.,21,pp.657-671 (1972)
MENDELSON, W.B., et al.,Sleep induction by an adrenal steroid in the rat,Psychopharmacology,93,pp.226-229 (1987)
BOWERS, B.J., et al.,Biochemical and Behavioral Effects of Steroids on GABAA Receptor Function in Long-and Short-Sleep...,Brain Res. Bull.,29,pp.57-68 (1992)
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota