Title:
１型糖尿病を予防するための方法および組成物
Document Type and Number:
Japanese Patent JP7137696
Kind Code:
B2
Abstract:
Provided herein, in one aspect, is a method of preventing or delaying the onset of clinical type 1 diabetes (T1D), comprising: providing a non-diabetic subject who is at risk for T1D; determining that the non-diabetic subject (1) is substantially free of antibodies against zinc transporter 8 (ZnT8), (2) is HLA-DR4+, and/or (3) is not HLA-DR3+; and administering a prophylactically effective amount of an anti-CD3 antibody to the non-diabetic subject.
Inventors:
Leon, Francisco
Herold, Kevan Sea.
Skyler Jay S.
Herold, Kevan Sea.
Skyler Jay S.
Application Number:
JP2021520987A
Publication Date:
September 14, 2022
Filing Date:
May 14, 2020
Export Citation:
Assignee:
PROVENTION BIO, INC.
International Classes:
A61K39/395; A61P3/10
Domestic Patent References:
| JP2009544761A | ||||
| JP2016042024A | ||||
| JP2010538017A | ||||
| JP2015522026A | ||||
| JP2016515599A |
Other References:
Diabetes Care, 2015, Vol.38, No.4, pp.644-651
Science Immunology, 2016, Vol.1, No.5, eaai7793
Science Immunology, 2016, Vol.1, No.5, eaai7793
Attorney, Agent or Firm:
Okuyama Shoichi
Tetsuo Matsushima
Nakamura Ayako
Soji Morimoto
Yu Tanaka
Akiko Mizushima
Kohei Arihara
Tetsuo Matsushima
Nakamura Ayako
Soji Morimoto
Yu Tanaka
Akiko Mizushima
Kohei Arihara