Title:
METHODS AND COMPOSITIONS FOR REDUCING IMMUNOGENICITY OF CHIMERIC NOTCH RECEPTORS
Document Type and Number:
Japanese Patent JP2022105139
Kind Code:
A
Abstract:
To provide nucleic acids for reducing the immunogenicity of chimeric Notch receptors.SOLUTION: A nucleic acid comprises a nucleotide sequence encoding a chimeric Notch polypeptide comprising, from N-terminal to C-terminal: a) an extracellular domain comprising a binding factor that specifically binds to an antigen; b) the receptor polypeptide comprising one or more proteolytic cleavage sites; c) an intracellular domain comprising a transcriptional regulator, wherein binding of the binding factor to the antigen induces cleavage of the Notch receptor polypeptide at the one or more proteolytic cleavage sites, thereby releasing the intracellular domain and the transcriptional regulator, and wherein the transcriptional regulator comprises a DNA binding domain of human origin and a transactivation domain of human origin.SELECTED DRAWING: Figure 1
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Inventors:
AMY GILBERT
VLADIMIR SLEPUSHKIN
PETER EMTAGE
ANSELM LEVSKAYA
SPENCER SCOTT
VLADIMIR SLEPUSHKIN
PETER EMTAGE
ANSELM LEVSKAYA
SPENCER SCOTT
Application Number:
JP2022075722A
Publication Date:
July 12, 2022
Filing Date:
May 02, 2022
Export Citation:
Assignee:
CELL DESIGN LABS INC
International Classes:
C12N15/62; A61K38/17; A61K48/00; A61P35/00; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/13; C12N15/63; C12P21/00
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office