Title:
細胞死を抑制する又は細胞増殖を高めるための方法及び組成物
Document Type and Number:
Japanese Patent JP5114418
Kind Code:
B2
Abstract:
The present invention provides compositions and methods that enhance cell survival. Such compositions feature chimeric polypeptides that include at least a GM-CSF receptor ligand and an anti-apoptotic moiety (e.g., a Bcl-2 protein family member). In one embodiment, the chimeric polypeptide is a GM-CSF-Bcl-xL chimeric polypeptide. The invention further includes methods of using chimeric polypeptides to enhance cell survival or inhibit cell death in a cell at risk of cell death.
Inventors:
Youul, Richard Jay.
Antignani, Antonella
Antignani, Antonella
Application Number:
JP2008536580A
Publication Date:
January 09, 2013
Filing Date:
September 08, 2006
Export Citation:
Assignee:
Government of the United States of America as Represented by the Secretary Department of Health and Human Services
International Classes:
C12N15/09; A61K35/12; A61K45/00; C07K14/47; C07K14/535; C07K16/28; C07K19/00; C12N5/07; C12N5/0793; C12N5/10; C12Q1/06
Domestic Patent References:
| JP2004535415A |
Foreign References:
| WO2005049073A1 | ||||
| WO2001012661A1 | ||||
| WO2005065121A1 | ||||
| WO2001060317A1 |
Other References:
Cancer Res.,2001年,Vol.61,p.7925-7933
J. Neurosci.,2002年,Vol.22, No.13,p.5423-5431
J. Neurosci. Res.,2005年 1月,Vol.79,p.628-637
Mol. Cell. Neurosci.,2002年,Vol.21,p.29-37
Ann. Neurol.,2002年,Vol.52,p.617-622
J. Biol. Chem.,2001年,Vol.276, No.49,p.46326-46332
J. Neurosci.,2002年,Vol.22, No.13,p.5423-5431
J. Neurosci. Res.,2005年 1月,Vol.79,p.628-637
Mol. Cell. Neurosci.,2002年,Vol.21,p.29-37
Ann. Neurol.,2002年,Vol.52,p.617-622
J. Biol. Chem.,2001年,Vol.276, No.49,p.46326-46332
Attorney, Agent or Firm:
Norio Saeki